Fasting Hyperbilirubinemia and Its Relationship to Free Fatty Acids and Triglycerides in the Horse

Naylor, Jonathan M.; Kronfeld, D. S.; Johnson, K.

doi:10.3181/00379727-165-40938

Cited by 31 publications

(32 citation statements)

References 3 publications

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“…During lipid mobilisation, FFA competes with bilirubin to get bound to ligandin . According to a previous report, there is a strong positive linear correlation between the serum increase in FFA and unconjugated bilirubin .…”

Section: Discussionmentioning

confidence: 89%

Effect of feed deprivation on selected parameters of lipid mobilisation and hepatic function in healthy Akhal Teke horses

Tóth¹,

Auth²,

Rompos³

et al. 2017

Equine Veterinary Journal

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Section: Discussionmentioning

confidence: 89%

Effect of feed deprivation on selected parameters of lipid mobilisation and hepatic function in healthy Akhal Teke horses

Tóth¹,

Auth²,

Rompos³

et al. 2017

Equine Veterinary Journal

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“…Elevated de novo lipogenesis and peripheral fatty acids mainly derived from lipolysis of adipose tissue contribute to the accumulation of hepatic fat in NAFLD [3], [41]. Bilirubin showed antilipolytic activity in animal models [42], [43] probably due to direct inhibition of triglyceride lipase [43]. On the other hand, serum bilirubin concentrations can influence free fatty acid metabolism [44].…”

Section: Discussionmentioning

confidence: 99%

A Cohort Study of Serum Bilirubin Levels and Incident Non-Alcoholic Fatty Liver Disease in Middle Aged Korean Workers

et al. 2012

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BackgroundSerum bilirubin may have potent antioxidant and cytoprotective effects. Serum bilirubin levels are inversely associated with several cardiovascular and metabolic endpoints, but their association with nonalcoholic fatty liver disease (NAFLD) has not been investigated except for a single cross-sectional study in a pediatric population. We assessed the prospective association between serum bilirubin concentrations (total, direct, and indirect) and the risk for NAFLD.Methods and FindingsWe performed a cohort study in 5,900 Korean men, 30 to 59 years of age, with no evidence of liver disease and no major risk factors for liver disease at baseline. Study participants were followed in annual or biennial health examinations between 2002 and 2009. The presence of fatty liver was determined at each visit by ultrasonography. We observed 1,938 incident cases of NAFLD during 28,101.8 person-years of follow-up. Increasing levels of serum direct bilirubin were progressively associated with a decreasing incidence of NAFLD. In age-adjusted models, the hazard ratio for NAFLD comparing the highest to the lowest quartile of serum direct bilirubin levels was 0.61 (95% CI 0.54–0.68). The association persisted after adjusting for multiple metabolic parameters (hazard ratio comparing the highest to the lowest quartile 0.86, 95% CI 0.76–0.98; P trend = 0.039). Neither serum total nor indirect bilirubin levels were significantly associated with the incidence of NAFLD.ConclusionsIn this large prospective study, higher serum direct bilirubin levels were significantly associated with a lower risk of developing NAFLD, even adjusting for a variety of metabolic parameters. Further research is needed to elucidate the mechanisms underlying this association and to establish the role of serum direct bilirubin as a marker for NAFLD risk.

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“…The precise mechanism is unknown. Increased concentration of plasma free fatty acids may cause a competition between free fatty acids and bilirubin for ligandin binding and hepatic uptake (Naylor et al, 1980). Competition with free fatty acids for this carrier-mediated uptake seems likely, particularly because horses and ponies experience high degrees of hyperlipidemia during fasting.…”

Section: Animal-related Changesmentioning

confidence: 99%

Pre-analytical factors affecting the results of laboratory blood analyses in farm animal veterinary diagnostics

Humann-Ziehank

Ganter

2012

Animal

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The quality of the laboratory diagnostic approach in farm animals can be severely affected by pre-analytical factors of variation. They induce increase/decrease of biochemical and hematological analyte concentrations and, as a consequence, they may cause unsuitable conclusions and decisions for animal health management and research projects. The pre-analytical period covers the preparation of sampling, the sampling procedure itself, as well as all specimen handling until the beginning of the specific laboratory analysis. Pre-analytical factors may have either an animal-related or a technique-related background. Animal-related factors cover daytime/season, meals/fasting, age, gender, altitude, drugs/anesthesia, physical exercise/stress or coinfection. Technique-related factors are the choice of the tube including serum v. plasma, effects of anticoagulants/gel separators, the anticoagulant/blood ratio, the blood collection procedure itself, specimen handling, contamination, labeling, storage and serum/plasma separation, transportation of the specimen, as well as sample preparation before analysis in the laboratory. It is essential to have proper knowledge about the importance and source of pre-analytical factors to alter the entire diagnostic process. Utmost efforts should be made to minimize controllable factors. Analytical results have to be evaluated with care considering that pre-analytical factors of variation are possible causes of misinterpretation.

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Fasting Hyperbilirubinemia and Its Relationship to Free Fatty Acids and Triglycerides in the Horse

Cited by 31 publications

References 3 publications

Effect of feed deprivation on selected parameters of lipid mobilisation and hepatic function in healthy Akhal Teke horses

Effect of feed deprivation on selected parameters of lipid mobilisation and hepatic function in healthy Akhal Teke horses

A Cohort Study of Serum Bilirubin Levels and Incident Non-Alcoholic Fatty Liver Disease in Middle Aged Korean Workers

Pre-analytical factors affecting the results of laboratory blood analyses in farm animal veterinary diagnostics

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