2022
DOI: 10.3390/nu14051093
|View full text |Cite
|
Sign up to set email alerts
|

Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers

Abstract: Elevated plasma levels of trimethylamine N-oxide (TMAO) have been proposed as a diet-derived biomarker of cardiometabolic disease risk. Caloric restriction is the most common dietary intervention used to improve cardiometabolic health; however, novel trends suggest a fasting-mimicking diet (FMD) as a more feasible alternative. FMD is a variation of intermittent fasting, based on caloric restriction and limitation of protein sources of animal origin, applied in daily cycles during a 5-day period. As TMAO is int… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
7
0

Year Published

2022
2022
2025
2025

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 13 publications
(7 citation statements)
references
References 64 publications
0
7
0
Order By: Relevance
“…Thus, it is not entirely surprising that our lifestyle treatment had less robust changes across participants, given the average levels were 3.46 ± 0.4 μM and 4.16 ± 0.7 μM in LCD and LCD+INT, respectively. These discrepancies are interesting since other work has demonstrated that both caloric restriction and specific macronutrient-targeted diets are effective at reducing circulating TMAO [ 11 , 14 , 23 ]. However, this previous dietary work was mainly focused on vegan or low-fat diets, which potentially reduced animal product consumption and subsequent choline and carnitine intake more than the present study.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Thus, it is not entirely surprising that our lifestyle treatment had less robust changes across participants, given the average levels were 3.46 ± 0.4 μM and 4.16 ± 0.7 μM in LCD and LCD+INT, respectively. These discrepancies are interesting since other work has demonstrated that both caloric restriction and specific macronutrient-targeted diets are effective at reducing circulating TMAO [ 11 , 14 , 23 ]. However, this previous dietary work was mainly focused on vegan or low-fat diets, which potentially reduced animal product consumption and subsequent choline and carnitine intake more than the present study.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, diets low in red meat reduce plasma TMAO, and individuals adhering to vegetarian diets demonstrate lower TMA [ 9 , 10 ]. Not surprisingly, hypocaloric diets have also been proposed to reduce TMAO, through both lower animal product consumption and overall caloric restriction [ 11 ]. Alternatively, aerobic exercise may reduce CVD risk through improvements to gut health and microbiota [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…For example, in a previous randomized controlled trial, subjects with heart failure assigned to the DASH group followed the DASH eating plan for 3 months and demonstrated better exercise capacity and quality of life [ 433 ]. Furthermore, the fasting-mimicking diet (FMD), a caloric restriction dietary intervention has been applied in a clinical study, indicating the benefit of FMD in reducing plasma levels of TMAO and the risk of CVDs [ 520 ].…”
Section: Promising Therapy Of Targeting the Gut Microbiota In Cvdsmentioning
confidence: 99%
“…One investigation on dietary interventions ( 57 ) in healthy subjects divided into a VEG group (usual dietary regimen + 4 servings of vegetables) and an FMD group (5-day hypocaloric diet) established that the plasma TMAO, fasting blood glucose, and C-peptide of subjects in the FMD group diminished considerably compared to the VEG group. This finding suggests intermittent fasting as a viable option for improving cardiometabolic health.…”
Section: Preventions and Treatments Targeting Tmaomentioning
confidence: 99%