Fat Graft Survival After Recipient Site Pretreatment With Fractional Carbon Dioxide Laser

Kim, Sang Hoon; Lee, Jun Ho; Kim, Tae-Gon; Kim, Yong-Ha; Chung, Kyu Jin

doi:10.1097/sap.0000000000001218

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…Several experimental studies have been conducted for recipient site preconditioning in search for improved fat graft survival, including administration of deferoxamine, VEGF, epidermal growth factor, erythropoietin, n‐acetylcysteine. and fractional carbon dioxide laser 13,45–49 . However, most of these modalities have limited clinical application due to their cost, concerns on oncologic safety, difficulties with administration of drugs and thermal damage induced by lasers 50–53 .…”

Section: Discussionmentioning

confidence: 99%

“…and fractional carbon dioxide laser. 13,[45][46][47][48][49] However, most of these modalities have limited clinical application due to their cost, concerns on oncologic safety, difficulties with administration of drugs and thermal damage induced by lasers. [50][51][52][53] Flacco et al demonstrated significantly improved fat graft volume retention at eighth week in mice, with preconditioning of the previously irradiated recipient site with deferoxamine, which is an iron-chelator.…”

Section: Discussionmentioning

confidence: 99%

“…Various experimental methods have been reported investigating different PBM modalities including red and near‐infrared PBM, blue light, green light, pulsed light‐emitting diodes, fractional carbon dioxide laser, and their effects on adipose tissue. Kim et al 13 have demonstrated beneficial effects of carbon dioxide laser on fat graft survival following 14 days after fat grafting when used as a preconditioning method in rats. Improved survival outcomes were attributed to upregulation of vascular endothelial growth factor (VEGF), increased microvessel growth and improved blood flow to the surrounding skin on the recipient site.…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation with polychromatic light (600–1200 nm) improves fat graft survival by increasing adipocyte viability, neovascularization, and reducing inflammation in a rat model

et al. 2021

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Objectives Unpredictability with the final volume and viability of the graft are the major concerns in fat grafting. An experimental study was conducted to increase graft retention using photobiomodulation (PBM) with polychromatic light in near‐infrared region (600–1200 nm) by utilizing its stimulatory effects on angiogenesis, neovascularization, adipocyte viability, and anti‐inflammatory properties. Methods A total of 24 rats were divided into four groups (n = 6) according to the applied polychromatic light protocol to the recipient site (none, before fat transfer, after fat transfer, and combined). In all groups, inguinal fat pad was excised, measured for volume and weight, and transferred to the dorsum of the rat. At the end of the experiment, fat grafts were harvested from the recipient site for volume and weight measurements, histological, and immunohistochemical evaluation. Results Intergroup comparison revealed that fat graft retention regarding weight and volume, was significantly superior in Group IV (p = 0.049 and p = 0.043, respectively), which polychromatic light was applied both before and after transfer of the graft. Hematoxylin–eosin and Masson's trichrome stained sections showed absence of necrosis, fibrosis, inflammation, cyst formation, and increased vascularization of both inner and outer zones of the grafts in Group IV. Also, immunohistochemical staining scores for perilipin (indicator for adipocyte viability), CD31 and VEGF (indicators for angiogenesis and neovascularization) were significantly higher (p < 0.001). Ki67 scores were significantly lower in this group because of anti‐inflammatory environment (p < 0.001). Conclusions Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation with polychromatic light (600–1200 nm) improves fat graft survival by increasing adipocyte viability, neovascularization, and reducing inflammation in a rat model

et al. 2021

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“…87,88 The most common techniques currently being investigated include volume expansion, implantation of alloplastic materials such as silicone, administration of cell-proliferation factors such as VEGF or IL-8, iatrogenic ischemia, and micro-needling. 89–91…”

Section: Recipient Sitementioning

confidence: 99%

Fat Grafting: Basic Science, Techniques, and Patient Management

Shauly

Gould

Ghavami³

2022

Plastic and Reconstructive Surgery - Global Open

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Summary: In this review, a summary of the rich history of autologous fat grafting is provided, and a comprehensive summary of the science and theory behind autologous adipocyte transplantation, as well as the techniques commonly used is described. These include recipient site preparation, harvesting, processing, and engraftment. In addition, important considerations for preoperative and postoperative management are discussed to maximize graft retention. Special considerations in grafting to the breast, face, and buttocks are also summarized.

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“…35,36 Teknik yang paling umum saat ini sedang diselidiki termasuk ekspansi volume, implantasi bahan alloplastic seperti silikon,pemberian faktor proliferasi sel seperti VEGF atau IL-8, iskemia iatrogenik, dan jarum mikro. [37][38][39] Ekspansi volume eksternal adalah metode di mana ekspander eksternal ditempatkan di lokasi penerima. Dalam penelitian pada hewan, telah terbukti meningkatkan tingkat proliferasi cangkok dan jumlah sel akhir, serta jumlah total adiposit dewasa.…”

Section: Situs Penerimaunclassified

Autologous Fat Grafting on the Right Leg : Sebuah Laporan Kasus

Fortuna¹,

Rasikarahma²

2022

Scientificj

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Pendahuluan: Autologous fat grafting menjadi semakin populer beberapa tahun terakhir dengan banyaknya aplikasi rekonstruksi pada payudara, wajah, pasca radiasi dan luka bakar, anomali kongenital, serta berbagai aplikasi estetika. Keuntungan prosedur ini adalah menggunakan bahan dari tubuh sendiri sehingga kecil kemungkinan terjadi reaksi alergi, jumlah lemak donor yang cukup banyak tersedia, serta dapat bertahan dalam beberapa tahun. Prosedur ini merupakan prosedur berisiko rendah dengan potensi komplikaisi seperti nekrosis lemak, pembentukan kista, selulitis, serta ketidakteraturan kontur. Metode: Pada laporan kasus ini akan dicantumkan tinjauan kepustakaan mengenai autologous fat grafting, serta laporan kasus dan diskusi. Pasien perempuan berusia 25 tahun datang ke poliklinik Bedah Plastik Rumah Sakit M.Djamil Padang dengan keluhan bekas luka pada betis kanan dan kulit terlihat mencekung pada bekas luka. Hasil: Pasien kemudian dilakukan liposuction dan fat graft pada cruris dextra dan diberikan obat pulang berupa antiyeri. Pada pasien ini terapi post operatif luka ditutup dengan menggunakan kasa dan plester kemudian disarankan untuk kontrol setiap bulannya.

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Fat Graft Survival After Recipient Site Pretreatment With Fractional Carbon Dioxide Laser

Abstract: Pretreatment of recipient site using fractional CO2 laser helped vascularization in the early stage in fat graft and solved the ischemic condition, so it improved fat survival rate.

Cited by 11 publications

References 20 publications

Photobiomodulation with polychromatic light (600–1200 nm) improves fat graft survival by increasing adipocyte viability, neovascularization, and reducing inflammation in a rat model

Photobiomodulation with polychromatic light (600–1200 nm) improves fat graft survival by increasing adipocyte viability, neovascularization, and reducing inflammation in a rat model

Fat Grafting: Basic Science, Techniques, and Patient Management

Autologous Fat Grafting on the Right Leg : Sebuah Laporan Kasus

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