Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index

Abstract

The association of the fat mass and obesity-associated gene () rs11642015 polymorphism with prediabetes, type 2 diabetes and obesity in certain populations has not been previously reported. A population-based study was conducted that included 490 type 2 diabetic, 471 prediabetic and 575 normal subjects. The main outcomes of the study were prediabetes, type 2 diabetes and obesity. Binary logistic regression was performed to estimate the association of rs11642015 with the risk of prediabetes, type 2 diabetes and obesity following adjustment for the corresponding confounders. A meta-analysis was also conducted to evaluate the association between rs11642015 and obesity. rs11642015 was significantly associated with prediabetes in the whole sample under the additive model [odds ratio (OR), 1.50; 95% confidence interval (CI), 1.17-1.93; P=0.002], particularly in females. The polymorphism remained consistently significant following adjustment for age and body mass index (BMI), showing an increased prediabetes risk with an additive effect (OR, 1.55; 95% CI, 1.19-2.01; P=0.001). In addition, a significant association was found for rs11642015 with prediabetes and type 2 diabetes under the dominant model. However, under the stringent Bonferroni's correction there was no evidence of positive associations for rs11642015 with obesity in the whole sample, females or males. Findings of the meta-analysis showed that rs11642015 was not predisposed to obesity. In conclusion, the T allele of rs11642015 is positively associated with an increased risk of prediabetes, even after adjustment for age and BMI, particularly in females. Subjects carrying the CT + TT genotype are predisposed to prediabetes and type 2 diabetes. Therefore, results of the population-based study and follow-up meta-analysis suggested that rs11642015 is not significantly associated with susceptibility to obesity.

FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men

“…A few reports have shown a sex-specific effect of FTO variants on conferring susceptibility to obesity/adiposity [43,44,46–49], and some reports suggest that differences in the fat distribution and/or physical activity between men and women might affect the effects of FTO variants on obesity/adiposity [44–46,49]. In addition to the possible sex-specific effects, the larger sample size of men compared with women and the difference in the case/control ratio between men and women (Table 1) might lead to gender differences in the association between rs1558902 and T2D or BMI max .…”

Troxerutin protects against diabetic cardiomyopathy through NF-κB/AKT/IRS1 in a rat model of type 2 diabetes

“…Previous epidemiological data has indicated that the total number of patients with diabetes may surpass 400 million by 2030 ( 1 ). Diabetes, which has become the fifth major cause of worldwide mortality after infectious disease, cardiovascular disease, cancer and trauma, is a progressive disease that is characterized by hyperglycemia ( 2 ), and may be classified into types 1 and 2 ( 2 ). The development of type 2 diabetes is associated with a high fat diet, sedentary lifestyle and obesity.…”

Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations

“…For example, the SNP on chromosome 12 (rs1169288) that overlaps HNF1A had previously been reported as a pleiotropic variant affecting cardiometabolic traits and CRP levels [ 72 ]. The FTO variant on chromosome 16 (rs11642015) is reported as pleiotropic SNP for inflammation and lipid traits [ 73 ], and associated with BMI adjusted diabetes [ 74 ].…”