Fat mass is negatively associated with bone mineral content in Koreans

Kim, Jee Hyun; Choi, Hyo Geun; Kim, M. J.; Shin, Chan Soo; Cho, N. H.

doi:10.1007/s00198-011-1808-6

Cited by 77 publications

(55 citation statements)

References 34 publications

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“…Similarly, previous studies [1432333435] found a negative correlation between fat mass and BMD after adjusting for BMI, whereas several studies that did not adjust for body weight found a positive correlation between fat mass and BMD [11232435]. Fat mass is a major component of body weight.…”

Section: Discussionmentioning

confidence: 60%

Association between Obesity and Bone Mineral Density by Gender and Menopausal Status

Salamat

Janghorbani

2016

Endocrinol Metab

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BackgroundWe investigated whether there were gender differences in the effect of obesity on bone mineral density (BMD) based on menopausal status.MethodsWe assessed 5,892 consecutive patients 20 to 91 years old who were referred for dual-energy X-ray absorptiometry (DXA) scans. All subjects underwent a standard BMD scan of the hip (total hip and femoral neck) and lumbar spine (L1 to L4) using a DXA scan and body size assessment. Body mass index was used to categorize the subjects as normal weight, overweight, and obese.ResultsBMD was higher in obese and overweight versus normal weight men, premenopausal women, and postmenopausal women. Compared to men ≥50 years and postmenopausal women with normal weight, the age-adjusted odds ratio of osteopenia was 0.19 (95% confidence interval [CI], 0.07 to 0.56) and 0.38 (95% CI, 0.29 to 0.51) for obese men ≥50 years and postmenopausal women. Corresponding summaries for osteoporosis were 0.26 (95% CI, 0.11 to 0.64) and 0.15 (95% CI, 0.11 to 0.20), respectively. Compared to men <50 years and premenopausal women with normal weight, the age-adjusted odds ratio of low bone mass was 0.22 (95% CI, 0.11 to 0.45) and 0.16 (95% CI, 0.10 to 0.26) for obese men <50 years and premenopausal women, respectively.ConclusionObesity is associated with BMD of the hip and lumbar spine and overweight and obese individuals have similar degrees of osteoporosis. This result was not significantly different based on gender and menopausal status, which could be an important issue for further investigation.

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Section: Discussionmentioning

confidence: 60%

Association between Obesity and Bone Mineral Density by Gender and Menopausal Status

Salamat

Janghorbani

2016

Endocrinol Metab

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“…A high lean mass and low fat mass exert protective effects on bone health, and a higher fat mass may be related to the detrimental effects on BMD [11]. Moreover, fat mass was inversely related to BMC after the removal of the mechanical loading effect in males and females [35]. In the current study, the whole-body fat mass was controlled as a confounding factor in the current study.…”

Section: Discussionmentioning

confidence: 99%

Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

et al. 2017

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ObjectiveThis study aimed to evaluate the relationship between insulin resistance and the bone mineral density (BMD) of femur and lumbar spine in Korean adults who are expected to exhibit near peak bone mass.MethodsData from the Korean National Health and Nutrition Examination Survey 2008–2010 were analyzed. A total of 2,750 participants aged 25−35 years were included. Insulin resistance was assessed using a homeostatic model assessment of insulin resistance (HOMA-IR) and serum fasting insulin.ResultsIn a multivariate linear regression analysis, the HOMA-IR was significantly inversely associated with the BMD of the total hip (TH, β = −0.052, P = 0.002), femoral neck (FN, β = −0.072, P<0.001), femoral trochanter (FTr, β = −0.055, P = 0.003), femoral intertrochanter (FITr, β = −0.041, P = 0.015), and lumbar spine (LS, β = −0.063, P = 0.001) among all study subjects after adjustment for gender, age, height, weight, whole body fat mass percentage, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, vitamin D, smoking, alcohol intake, physical activity, education level, and household income in both genders as well as labor, the use of oral contraceptives, and age at menarche in females. The serum fasting insulin was significantly inversely associated with the BMD of the TH (β = −0.055, P = 0.001), FN (β = −0.072, P<0.001), FTr (β = −0.055, P = 0.003), FITr (β = −0.045, P = 0.009), and LS (β = −0.064, P = 0.001) among all subjects in a multivariate linear regression analysis.ConclusionOur results suggest that insulin resistance may be independently and inversely associated with the near peak bone mass of the femur and lumbar spine.

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“…Recently, using trabecular bone score, a bone parameter derived from DXA images, considered a good estimation index for bone microarchitecture. Kim et al [70] reported that VAT had a detrimental effect on bone microarchitecture at the lumbar spine and a beneficial effect associated with SAT in Korean postmenopausal women. Another study conducted in a large cohort of middle-aged adults, by Zhang et al, reported an inverse relationship between VAT and cortical and trabecular bone independently of age, sex and BMI [71].…”

Section: Effects Of Fat and Obesity On Bone Mass And Qualitymentioning

confidence: 99%

Obesity is a concern for bone health with aging

2017

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Accumulating evidence supports a complex relationship between adiposity and osteoporosis in overweight/obese individuals, with local interactions and endocrine regulation by adipose tissue on bone metabolism and fracture risk in elderly populations. This review was conducted to summarize existing evidence to test the hypothesis that obesity is a risk factor for bone health in aging individuals. Mechanisms by which obesity adversely affects bone health are believed to be multiple, such as an alteration of bone-regulating hormones, inflammation, oxidative stress, the endocannabinoid system, that affect bone cell metabolism are discussed. In addition, evidence on the effect of fat mass and distribution on bone mass and quality is reviewed together with findings relating energy and fat intake with bone health. In summary, studies indicate that the positive effects of body weight on bone mineral density cannot counteract the detrimental effects of obesity on bone quality. However, the exact mechanism underlying bone deterioration in the obese is not clear yet and further research is required to elucidate the effect of adipose depots on bone and fracture risk in the obese population.

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Fat mass is negatively associated with bone mineral content in Koreans

Abstract: This study demonstrated that fat mass was inversely related to BMC after removing the mechanical loading effect in Korean men and women. Moreover, abdominal obesity as measured by WC was significantly associated with BMC independent of total fat mass.

Cited by 77 publications

References 34 publications

Association between Obesity and Bone Mineral Density by Gender and Menopausal Status

Association between Obesity and Bone Mineral Density by Gender and Menopausal Status

Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010

Obesity is a concern for bone health with aging

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