Fat-soluble micronutrients and metabolic syndrome

Goncalves, Aurélie; Amiot, Marie-Josèphe

doi:10.1097/mco.0000000000000412

Cited by 41 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a randomized clinical trial with MetS patients, vitamin E was seen to exert beneficial effects on cytokines and the lipid profile [ 175 ]. Moreover, different studies have found that vitamin E could ameliorate the pathologic conditions associated with MetS such as hyperglycemia or obesity, although more studies in patients are needed to prove the consistency of these findings [ 175 , 176 ].…”

Section: Nutrients (Well-being Through Feeding)mentioning

confidence: 99%

Nutrition, Bioenergetics, and Metabolic Syndrome

et al. 2020

View full text Add to dashboard Cite

According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world’s population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden.

show abstract

Section: Nutrients (Well-being Through Feeding)mentioning

confidence: 99%

Nutrition, Bioenergetics, and Metabolic Syndrome

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is common knowledge that diets rich in fruits and vegetables are associated with improved health and longevity and, since carotenoids are abundant in plants, many studies correlated the presence of these pigments with a healthy status in people (recently reviewed in [110,111,112]). Nevertheless, these observations could be merely associations based on the chemical properties of carotenoids, i.e., carotenoids are decreased in obesity because these compounds accumulate in the adipose tissue as this tissue works as a “trap” for lipophilic molecules.…”

Section: β-Carotene and Obesity; Key Findings And Technical Limitamentioning

confidence: 99%

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

2019

View full text Add to dashboard Cite

Over the past decades, obesity has become a rising health problem as the accessibility to high calorie, low nutritional value food has increased. Research shows that some bioactive components in fruits and vegetables, such as carotenoids, could contribute to the prevention and treatment of obesity. Some of these carotenoids are responsible for vitamin A production, a hormone-like vitamin with pleiotropic effects in mammals. Among these effects, vitamin A is a potent regulator of adipose tissue development, and is therefore important for obesity. This review focuses on the role of the provitamin A carotenoid β-carotene in human health, emphasizing the mechanisms by which this compound and its derivatives regulate adipocyte biology. It also discusses the physiological relevance of carotenoid accumulation, the implication of the carotenoid-cleaving enzymes, and the technical difficulties and considerations researchers must take when working with these bioactive molecules. Thanks to the broad spectrum of functions carotenoids have in modern nutrition and health, it is necessary to understand their benefits regarding to metabolic diseases such as obesity in order to evaluate their applicability to the medical and pharmaceutical fields.

show abstract

“…They are also associated with a reduced ability to incorporate lipophilic compounds into cells, since VE is highly hydrophobic, and cannot adequately access inside cells to carry out its functions, including antioxidant activity. In this scenario, obese people are especially vulnerable to suffering dyslipidemia and chronic low-grade inflammation [129], and the presence of apolipoprotein risk variants would impair taking advantage of the properties of vitamin E, even when following current dietary recommendations.…”

Section: Influence Of Genetic Variants On Transport Management Amentioning

confidence: 99%

Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances

2018

View full text Add to dashboard Cite

Vitamin E (VE) has a recognized leading role as a contributor to the protection of cell constituents from oxidative damage. However, evidence suggests that the health benefits of VE go far beyond that of an antioxidant acting in lipophilic environments. In humans, VE is channeled toward pathways dealing with lipoproteins and cholesterol, underlining its relevance in lipid handling and metabolism. In this context, both VE intake and status may be relevant in physiopathological conditions associated with disturbances in lipid metabolism or concomitant with oxidative stress, such as obesity. However, dietary reference values for VE in obese populations have not yet been defined, and VE supplementation trials show contradictory results. Therefore, a better understanding of the role of genetic variants in genes involved in VE metabolism may be crucial to exert dietary recommendations with a higher degree of precision. In particular, genetic variability should be taken into account in targets concerning VE bioavailability per se or concomitant with impaired lipoprotein transport. Genetic variants associated with impaired VE liver balance, and the handling/resolution of oxidative stress might also be relevant, but the core information that exists at present is insufficient to deliver precise recommendations.

show abstract

Fat-soluble micronutrients and metabolic syndrome

Cited by 41 publications

References 30 publications

Nutrition, Bioenergetics, and Metabolic Syndrome

Nutrition, Bioenergetics, and Metabolic Syndrome

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances

Contact Info

Product

Resources

About