1959
DOI: 10.1056/nejm195910222611704
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Fatal Amebiasis Complicating Corticosteroid Management of Pemphigus Vulgaris

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Cited by 39 publications
(5 citation statements)
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“…There is agreement on the distinctive fea tures of strongyloidiasis lesions [2-4] and on the influence of corticosteroid therapy in ag gravating many types of infections [5][6][7], Our case seems to show a close relationship between steroid administration and the on set of urticaria. Thanks to these agents a pre sumably long-standing infection was evi denced after several years of dormancy [8].…”
Section: Discussionsupporting
confidence: 66%
“…There is agreement on the distinctive fea tures of strongyloidiasis lesions [2-4] and on the influence of corticosteroid therapy in ag gravating many types of infections [5][6][7], Our case seems to show a close relationship between steroid administration and the on set of urticaria. Thanks to these agents a pre sumably long-standing infection was evi denced after several years of dormancy [8].…”
Section: Discussionsupporting
confidence: 66%
“…Early in pregnancy the level of plasma corticosteroids increase and although there is an increase in the concentration and binding capacity of transcortin, 26% ARMON there is still an overall increase in the free plasma cortisol level (Hytten and Lind, 1973). It is known that corticosteroids may exacerbate latent amoebiasis and several fatalities have been reported in a variety of circumstances where steroids have been used in the treatment of coincidental conditions (Eisert et al, 1959;Lewis and Antia, 1969;Seale et al, 1977). The condition of patient No.…”
Section: Discussionmentioning
confidence: 99%
“…In animal studies, immune suppression after thymectomy or splenectomy results in an increased incidence of ALA ( 9 ). Suppressed cellular immunity caused by use of steroids and malnourishment predispose to fatal amebiasis ( 10 ). In the present study, 90% of patients had CD4 cell counts <350/mm 3 , which implies that immune suppression by HIV infection may be another risk factor for ALA.…”
mentioning
confidence: 99%