2015
DOI: 10.1007/s11046-015-9960-8
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Fatal Cases of Bloodstream Infection by Fusarium solani and Review of Published Literature

Abstract: Fusarium species are ubiquitously present in environment and are well known as human pathogens with high mortality rate in immunocompromised patients. We report here two cases where immunocompromised patients developed fatal bloodstream infections by this organism. Isolates were further identified by ITS1 region sequencing which confirmed them as Fusarium solani. Antifungal susceptibility testing was done following CLSI M38-A2 guidelines to amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole,… Show more

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Cited by 23 publications
(15 citation statements)
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“…Fusarium is a common saprophytic fungus that is found in the soil, air, and water. Although Fusarium species were first isolated as phytopathogens (plant pathogens), they can cause fixed (onychomycosis and fungal keratitis) and systemic infections in humans, especially in immunocompromised patients (4,5,9). These opportunistic fungi caused high morbidity and mortality rates among patients with malignancies, severe T cell immunodeficiency, and prolonged neutropenia.…”
Section: Discussionmentioning
confidence: 99%
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“…Fusarium is a common saprophytic fungus that is found in the soil, air, and water. Although Fusarium species were first isolated as phytopathogens (plant pathogens), they can cause fixed (onychomycosis and fungal keratitis) and systemic infections in humans, especially in immunocompromised patients (4,5,9). These opportunistic fungi caused high morbidity and mortality rates among patients with malignancies, severe T cell immunodeficiency, and prolonged neutropenia.…”
Section: Discussionmentioning
confidence: 99%
“…Persistent fever and skin lesions are the main symptoms despite antibacterial therapy (3). Recent studies have shown that Fusarium species, mostly cause fungemia in immunosuppressed patients (4)(5)(6). Limited infections occur in both immunocompetent and immunocompromised hosts, however disseminated fusariosis regularly occur in patients with hematological disorders, cancer pa-tients, and the solid organ transplant recipients (7).…”
Section: Introductionmentioning
confidence: 99%
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“…Severe paracoccidioidomycosis in a 14-year-old boy 200 1/1 [63] a Google Scholar/Scopus [41,42], France [43,44], India [45,46], Italy [47], Iran [48], Japan [49], Malaysia [50], Poland [51], UK [52], and USA [53,54]. There were no other discernible features among this group of case reports to account for the high downloads and citations except for a novelty or rarity of fungal pathogens, for example reports of two cases of multidrug-resistant yeast (Fereydounia khargensis) and of black-grain eumycetoma caused by the rare fungal pathogen Medicopsis romeroi [50,52].…”
Section: High Downloads and Citationsmentioning
confidence: 99%
“…is responsible for significant economic losses in the agricultural field worldwide 3 due to difficulties in management of diseases caused by this species 4 . Similarly, in the medical field, different Fusarium species have been related to local or invasive infections in both immunodepressed and immunocompetent individuals 5,6,7 .…”
Section: Introductionmentioning
confidence: 99%