Fatal Clindamycin‐Induced <scp>D</scp>rug <scp>R</scp>ash with <scp>E</scp>osinophilia and <scp>S</scp>ystemic <scp>S</scp>ymptoms (DRESS) Syndrome

Quidley, April Miller; Bookstaver, P. Brandon; Gainey, Andrew B.; Gainey, Matthew D.

doi:10.1002/phar.1142

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…Her condition rapidly deteriorated despite the fast discontinuation of the medication and even IVIG administration. Hepatic involvement is proposed a predictor of poor prognosis in this patient [ 68 ]. However, the two other cases also experienced liver involvement but survived.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were "DRESS syndrome," "drug-induced hypersensitivity syndrome (DIHS)," "antibiotics," "antimicrobial," and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS.

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Section: Discussionmentioning

confidence: 99%

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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“…Conversely, not all patients treated with clindamycin develop kidney diseases. The exact mechanism of clindamycin-induced AKI requires further study (11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

Clindamycin-induced Kidney Diseases: A Retrospective Analysis of 50 Patients

Wan

Wang

et al. 2016

Intern. Med.

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Objective There are many adverse reactions due to clindamycin, but kidney diseases (acute kidney injury, AKI) are uncommon. However, in recent years, the rate of clindamycin-induced kidney diseases has increased. We analyzed 50 patients with clindamycin-induced kidney diseases retrospectively, and investigated the characteristics of these kidney diseases in order to provide a reference for rational clinical drug use and to reduce drug-induced organ damage. Methods We investigated 50 patients diagnosed with clindamycin-induced kidney diseases retrospectively at the Department of Nephrology, Shandong University Qilu Hospital, from January 2009 to December 2013. The parameters included in our study were age, sex, clinical manifestations, efficacy and prognosis. Results All patients were diagnosed with clindamycin-induced kidney diseases within 48 hours of the application of clindamycin at 1.0-2.0 g/day. The patients included 29 women and 21 men. Most of the enrolled patients were 20-59 years old. Fifty-one patients were diagnosed with AKI stage 3 upon admission. Thirtythree had episodes of gross hematuria, but fever, skin rash and eosinophilia were rare. Urine analysis revealed mild proteinuria and severe tubular dysfunction. In the majority of patients, AKI was severe and required renal replacement therapy, but renal function in all patients had recovered significantly two months after discharge. Conclusion Clindamycin-induced AKI is largely reversible and is associated with episodes of gross hematuria. Clinicians should use clindamycin rationally and reduce the incidence of adverse reactions.

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“…Facial skin and oral mucosa were always reported as the initial site of such a lesion (Croy, Buehrle, & Austin Szwak, 2017; Karakayali et al., 2017; Sampson, Klinkova, Vitko, & Casanas, 2018), some of which sometimes occurred only in oral‐maxillofacial system (Nitta et al., 2019). Additionally, other severe cutaneous lesions attacking oral‐maxillofacial part were also investigated, such as drug reaction with eosinophilia and systemic symptoms (Miller Quidley, Bookstaver, Gainey, & Gainey, 2012; Tian, Mohan, & Stallings, 2010), hypersensitivity syndrome (Nakamura, Watamatsu, & Muto, 2013; Papakonstantinou et al., 2018), and sweet syndrome (Kandula, Burke, & Goldfarb, 2010).…”

Section: Oral‐maxillofacial Adverse Events Related To Antimlarialsmentioning

confidence: 99%

Oral‐maxillofacial adverse events related to antimalarials

Wang

Jiang

et al. 2020

Oral Diseases

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Malaria is a worldwide parasitic disease, which affects millions of lives every year. Various medications are recommended by WHO for prevention and treatment of malaria. However, adverse events caused by antimalarials were frequently reported, some of which were severe and fatal. Disorders of many organs related to antimalarials have been well recognized, whereas few studies concentrated on the relationship between antimalarials and oral‐maxillofacial system health. Current review generalized the relevance of antimalarials to the health of oral‐maxillofacial part and raised an urgent need to form a standard management for antimalarial‐related oral‐maxillofacial adverse events.

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Fatal Clindamycin‐Induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome

Cited by 16 publications

References 13 publications

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Clindamycin-induced Kidney Diseases: A Retrospective Analysis of 50 Patients

Oral‐maxillofacial adverse events related to antimalarials

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