Fatal colchicine toxicity

Simons, Richard J.; Kingma, Douglas W.

doi:10.1016/0002-9343(89)90315-x

Cited by 32 publications

(13 citation statements)

References 5 publications

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“…It was evaluated that plasmopheresis cannot be efficient for treatment. Because hemodialysis and plasma exchange cannot be effective at colchicine intoxication, since colchicine rapidly disperses into tissues and is engaged into cells with high affinity [19,22,23].…”

Section: Discussionmentioning

confidence: 99%

The etiology and autopsy findings in Colchicine intoxication-related deaths

İritaş¹,

Dinç²,

Akduman³

et al. 2016

Med-Science

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Colchicine is a drug which has a very narrow therapeutic range. This drug has been commonly used for Familial Mediterranean Fever (FMF), Behçet's disease, gout arthritis and acute pseudo gout attacks. In this study, the investigation reports and autopsy reports written by the Council of Forensic Medicine of Ankara between the years 2010-2014 were retrospectively analyzed to find out presence in the cases related to colchicine. Six cases were identified as colchicine intoxication, while three of them used colchicine for medical purpose. In four cases, colchicine was found to have been used for suicidal purpose. Among these four cases, two used colchicine for treatment. In all of our cases, colchicine was detected in bile specimen. Alveolar pulmonary edema and petechial hemorrhage were observed in the lung in all cases. Colchicine was detected in blood in four of the cases. In two cases, the concentration was found to be in therapeutic ranges (0,012 mg/L and 0,018 mg/L), while the other two, in lethal levels (0.099 mg/L and 0,264 mg/L). The most frequent histopathological finding is alveolar pulmonary edema in colchicine intoxication autopsies. Colchicine is widely used alkaloid drugs with narrow therapeutic ranges. More than 0.8 mg / kg in the acute high dose has usually fatal effects. The deaths resulted from colchicine intoxication are mainly suicide-oriented. Similar to other suicides with medicines, they are common among women. In our cases, colchicine was used for intention of suicide in four incidents (66, 66%).

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Section: Discussionmentioning

confidence: 99%

The etiology and autopsy findings in Colchicine intoxication-related deaths

İritaş¹,

Dinç²,

Akduman³

et al. 2016

Med-Science

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“…Colchicine intoxication has been described in a variety of clinical settings, most commonly after suicidal intent 6–11 . Also reported are accidental or medicinal overdose, 1,12–23 homicidal poisoning, 24 mistaken ingestion of colchicine‐containing plants, 25–27 and high‐dose colchicine for cancer chemotherapy 28–32 …”

Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis-like reaction secondary to colchicine overdose

Arroyo¹,

Sanders²,

Yee³

et al. 2004

Br J Dermatol

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“…Several additional iv uses include treatment of familial Mediterranean fever, pericarditis, primary biliary cirrhosis, amyloidosis, and Behçet's syndrome . [11][12][13] It should not be given intramuscularly or subcutaneously, as it causes severe local irritation.…”

Section: Intravenous Preparation (Iv)mentioning

confidence: 99%