Fatal DRESS Syndrome Without Eosinophilia After Coronary Artery Bypass Grafting

Abstract

syndrome (Drug reaction with eosinophilia and systemic symptom) is characterized by the presence of at least three of the following: fever, rash, eosinophilia, atypical circulating lymphocytes, lymphadenopathy and hepatitis. 1 The estimated frequency of DRESS syndrome varies between 1/1000-1/10000, and the mortality rate prediction is 10%. 1 The diagnosis of DRESS should be kept in mind when a skin rash, fever, hypereosinophilia and organ involvement is present. Liver is the most common affected organ. Cutaneous manifestations generally occur between 2 and 6 weeks aſter the first dose of culprit drug. 2 Besides the systemic glucocorticoid therapy, intravenous immunoglobulin therapy is essential for life-threatening forms.

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome That Develops After Hysterectomy Surgery

“…It resulted in death on the 7 th day despite intravenous immunoglobulin (IVIG) treatment on the 3 rd . 10 Although corticosteroids are the first-line treatment, IVIG treatment should be added for five days in severe cases of bone marrow failure or fulminant hepatitis. Another critical issue that determines the prognosis is the responsible drug.…”