Fatal Granulomatosis of the Respiratory Tract (Lethal Midline Granuloma-Wegener's Granulomatosis)

Midline Granuloma

“…There is some debate as to whether the two types of non-healing granuloma of the nose are somewhat similar but actually different disease processes or merely synonyms for the same disorder (Blatt et al 1959, Brown & Woolner 1960.…”

“…Whether or not this is due to auto-immune antibodies formed by the cells of the nose, or other organs, remains to be determined. Blatt et al (1959) suggested that some noxious substancechemical, physical or more likely an infectious organismmight bring about local tissue destruction in the respiratory tract which, acting as auto-antigen, might react with autoantibodies and produce a state of hypersensitivity.…”

Granuloma Gangraenescens, a Fatal Disease of the Face

“…To achieve this, antibiotic treatm ent of the secondary infection is prim arily indicated. In view of the vascular necrosis, which m ay be explained as an expression of allergic reactions, the adm inistration of ACTII or prednisone is desirable (Blatt et at., 1959;Hagens, 1962).…”

Wegener's Granulomatosis—A Clinical and Radiological survey

“…This contrasts with swollen turbinates due to infection or allergy, causing opacity of the antra. The earliest site of destruction is the septal cartilage of the nose, then the perpendicular plates of the ethmoids, the vomer and the turbinates (Blatt, Seltzer, Rubin, Furstenberg, Maxwell and Schull, 1959).…”