Fatal group C streptococcal infection due to transfusion of a bacterially contaminated pooled platelet unit despite routine bacterial culture screening

Lessa, Fernanda C.; Leparc, Germán F.; Benson, Kaaron; Sanderson, Roger; Beneden, Chris Van; Shewmaker, Patricia L.; Jensen, Bette; Arduino, Matthew J.; Kuehnert, Matthew J.

doi:10.1111/j.1537-2995.2008.01802.x

Cited by 29 publications

(37 citation statements)

References 30 publications

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“…SDSE was isolated from both the residual blood component bag and the recipient. A donor throat swab specimen collected 20 days after donation still contained SDSE [55]. These observations call for the implementation of improved safety measures for platelet concentrates.…”

Section: Perspectives Concerning Emerging Infectious Diseasementioning

confidence: 89%

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Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features

Takahashi

Ubukata

Watanabe

2011

Journal of Infection and Chemotherapy

101

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Section: Perspectives Concerning Emerging Infectious Diseasementioning

confidence: 89%

“…Recently, fatal or near-fatal transfusion-transmitted infections involving platelet concentrates have been reported from some countries other than Japan [55][56][57]. SDSE was isolated from both the residual blood component bag and the recipient.…”

Section: Perspectives Concerning Emerging Infectious Diseasementioning

confidence: 99%

Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features

Takahashi

Ubukata

Watanabe

2011

Journal of Infection and Chemotherapy

101

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“…Bacterial culture technics present a risk of false-negative results attributed to time of incubation and period of sampling. Septic reactions after transfusion of PC unit despite this screening by culture have already been reported 16 17. Pathogen-inactivation techniques are new, promising methods that have demonstrated their efficacy in reducing unit contamination, and are progressively utilised in Europe 18…”

Section: Discussionmentioning

confidence: 99%

Septic shock during platelet transfusion in a patient with acute myeloid leukaemia

et al. 2013

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Although rare, transfusion-associated bacterial contamination (TABC) is nowadays the main risk associated with platelet concentrate (PC) transfusion. Consequences vary from spontaneously resolving symptoms to severe sepsis and death. In this report we have summarised a case of bacterial contamination and sepsis during PC transfusion in a patient with acute myeloid leukaemia. Fifteen minutes after the PC transfusion began, she developed chills and rapidly worsened to septic shock. The episode was managed appropriately. The patient's blood cultures and PC unit cultures grewEscherichia coli. The microbiological susceptibilities of isolates from the patient and platelet bag were identical. No other source ofE coliwas found. Donor and blood products issued from the same donation investigations were negative. The causality between sepsis and PC transfusion might be difficult to confirm. As no method is available in daily practice to eliminate TABC risk, physicians should always consider TABC by immediately stopping the transfusion and conducting appropriate investigations.

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“…The frequency of a false-positive result (which means, no microorganisms could be cultured from the bottle flagged positive) was about two-fold higher for the anaerobic bottles. of Platelet Concentrates in the Netherlands 253 However, based on reported cases [8][9][10], it is clear that falsenegatives occur, but no hard data on the frequency in regular screening could be derived from these reports. Recently, several studies reported on the frequency of false-negatives, one for apheresis PCs [11] and two for buffy coat-derived PCs [12,13], being around 0.1%.…”

Section: Rate Of Initial Positive Cultures In the Screeningmentioning

confidence: 98%

10 Years Experience with Bacterial Screening of Platelet Concentrates in the Netherlands

Korte¹

2011

Transfus Med Hemother

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Background: Contamination of platelets with bacteria is the major microbiological risk of blood transfusion. Screening for bacterial contamination can reduce the frequency of bacterial transmission considerably. In the present paper, the results of 10-year screening in the Netherlands are described. Methods: All platelet concentrates were cultured with the BacT/Alert culturing system with large volume (7.5 ml) cultures in either an aerobic or an anaerobic bottle. Products were released on a ‘negative-to-date’ basis. Results: After introduction of the diversion of the first milliliters of collected blood, the number of positive screening cultures decreased significantly from 0.85% to 0.37%. The frequency of transfusion-transmitted bacterial infections by platelet concentrates is currently less than 1 per 2 years in the Netherlands. Conclusion: Over a period of 10 years the bacterial screening system for platelet concentrates proved to result in a safe system with respect to microbiological infection as a result of platelet transfusions.

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Fatal group C streptococcal infection due to transfusion of a bacterially contaminated pooled platelet unit despite routine bacterial culture screening

Cited by 29 publications

References 30 publications

Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features

Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features

Septic shock during platelet transfusion in a patient with acute myeloid leukaemia

10 Years Experience with Bacterial Screening of Platelet Concentrates in the Netherlands

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