Fatal Leptomeningeal Melanoma in Neurocutaneous Melanosis

Furtado, Sofia; Furtado, Sunil V.; Ghosal, Nandita; Hegde, Alangar S.

doi:10.1111/j.1525-1470.2011.01424.x

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…It develops from a congenital error in embryonic neuroectodermal morphogenesis resulting in abnormal proliferation of melanin producing cells within the skin and leptomeninges [26].The progressive malignant potential of this lesion as documented on histopathological examination and seen clinically at tumour recurrence has not been documented before. Prognosis in patients harboring such an intracranial lesion in general is poor, as evidenced by the early recurrence after adjuvant therapy [27]. To conclude, we present an interesting case series of MM with varied histopathological diagnosis which necessitates the need for the clinicians to be aware of these common and uncommon, neoplastic and non-neoplastic lesions as this may facilitate the therapeutic planning and predict the course of disease.…”

Section: Discussionmentioning

confidence: 94%

A clinicopathological study of diagnostically challenging meningioma mimics

et al. 2011

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The occurrence of neoplastic and nonneoplastic dural based masses that mimic meningiomas is infrequent and may not be considered during radiological and intraoperative analysis. We describe single institute study of 20 such rare cases. This study included total of 20 cases of meningioma mimics. The clinical, radiological and histopathological findings were evaluated. Tissue fixed in 10% formalin was routinely processed and 5 μ thick sections were cut and stained with hematoxylin & eosin. Histochemistry and immunohistochemistry using avidin-biotin complex immunoperoxidase method was done wherever indicated. In the present study group, 15 were male and 5 female with a male: female ratio of 3:1. The age ranged from 14 to 78 years. Radiologically all these lesions were extra-axial in location, predominantly hypointense on T2W, isointense on T1W images and showed intense homogenous enhancement on contrast administration. Four cases were in pediatric age group with histopathological diagnosis of Rosai Dorfman disease, medulloblastoma, hemangiopericytoma and malignant melanoma. In the adult population, the histopathological diagnoses were hemangiopericytoma, undifferentiated sarcoma, extraskeletal osteosarcoma, Rosai Dorfman disease, medulloblastoma, and metastases from systemic malignancies. Of the total 6 cases of metastases 1 was nonseminomatous germ cell tumor from a primary in testis, 1 was adenocarcinoma from an unknown primary, and 4 were adenocarcinoma from lung. There was a single case of dural based frontal lobe malignant melanoma with congenital hairy nevi on anterior chest wall, scalp, anterior abdominal wall and inguinal region. As the management and biologic behaviour of many of the MM are different, it is essential to familiarize ourselves to them.

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Section: Discussionmentioning

confidence: 94%

A clinicopathological study of diagnostically challenging meningioma mimics

et al. 2011

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“…Moreover, the prognosis of patients with NCM is poor, even if the intracranial lesion is diagnosed as benign melanocytosis[ 16 ]. According to the literature, most patients die of benign melanocyte overgrowth or malignant transformation within 3 years after symptom onset[ 27 ]. In the literature, 15 patients died during follow-up (71%), the survival status of 3 patients was unknown, and 3 patients survived for a long time.…”

Section: Discussionmentioning

confidence: 99%

Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature

Liu¹,

Wang²,

Liu³

et al. 2022

WJCC

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BACKGROUND Neurocutaneous melanosis (NCM) is a rare congenital, nonhereditary neurocutaneous syndrome that mainly occurs in children; adult NCM is very rare. Due to its rarity, the clinical features and treatment strategies for NCM remain unclear. The purpose of this study was to explore the clinical features, diagnosis, treatment and prognosis of NCM in adults. Most intracranial meningeal melanomas are solid masses, and cystic-solid malignant melanomas are very rare. Due to the lack of data, the cause of cystic changes and the effect on prognosis are unknown. CASE SUMMARY A 41-year-old woman was admitted to the hospital with intermittent headache for 1 mo. Magnetic resonance imaging (MRI) showed a 4.7 cm × 3.6 cm cystic-solid mass in the left temporal lobe with peritumoral edema. The entire mass was removed, and postoperative pathology indicated malignant melanoma. CONCLUSION MRI is the first-choice imaging approach for diagnosing central nervous system diseases in NCM patients, although cerebrospinal fluid may also be used. At present, there is no optimal treatment plan; gross total resection combined with BRAF inhibitors and MEK inhibitors might be the most beneficial treatment.

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“…None of them discuss factors that might influence the prognosis. The majority of the papers describe pediatric patients (1-3,5-10, [12][13][14][15][17][18][19][20][21][22][23][24][25][26][27][28][29][31][32][33][34][35][36][37][38][40][41][42][43][44][45][46][47][48][49][51][52][53]; while only five are centered on adults (16,25,30,50,54). The typical cutaneous aspects of NCM were described in all cases.…”

Section: Casementioning

confidence: 99%

Neurocutaneous melanosis in infancy: always a dismal prognosis?

Tamburrini¹,

Colosimo²,

Massimi³

et al. 2019

Turkish Neurosurgery

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AIM:To analyze the current literature on neurocutaneous melanosis (NCM), as well as, our cases, in order to better define the prognosis and the presence of risk factors affecting it, thus, offering better information to the parents. MATERIAL and METHODS:Two cases observed at the Pediatric Neurosurgery Unit of the Catholic University Medical School in Rome are described. Both of them had cutaneous stigmata and cerebral MR evidence of intracranial melanin deposits. These two children showed a very different clinical course. RESULTS:The present study enlighten the differences among the two cases and review the literature on the subject, with the attempt to understand which are clinical and disease related factors that might influence the prognosis. CONCLUSION:Beside malignant features of cutaneous melanotic lesions, the presence of hydrocephalus at diagnosis and the early appearance of clinical symptoms, when appearing contemporarily, are predicting the rapid progression of the disease and a worse prognosis.

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Fatal Leptomeningeal Melanoma in Neurocutaneous Melanosis

Cited by 10 publications

References 13 publications

A clinicopathological study of diagnostically challenging meningioma mimics

A clinicopathological study of diagnostically challenging meningioma mimics

Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature

Neurocutaneous melanosis in infancy: always a dismal prognosis?

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