Fatal necrotizing Candida esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis

Piubelli, Mario Luiz Marques; Felipe-Silva, Aloísio; Kanegae, Márcia Yoshie; Campos, Fernando Peixoto Ferraz de

doi:10.4322/acr.2018.070

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…Cardinal clinical features of cutaneous leukocytoclastic angiitis include palpable purpura, lower extremity location, small vessel involvement. [3][4][5] Only one-third of patients may present with trunk and upper extremity involvement as seen in our case. 6 LCV is idiopathic in approximately 50% of the cases.…”

Section: Discussionmentioning

confidence: 49%

The enigma of adult onset Henoch Schoenlein purpura and leucocytoclastic Vasculits: a case report

et al. 2021

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<p class="abstract">Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis is a small vessel inflammatory disease which mainly involves the postcapillary venules. It can be idiopathic or secondary to connective tissue diseases, infection, malignancy. A 39 year old male presented with a recurrent episode of multiple palpable purpurae over the legs, trunk, back and upper limbs with diffuse abdominal pain, bloody diarrhoea and arthralgia. Anti-nuclear antibodies (ANA) were positive, but ANA profile was equivocal. Histopathological examination confirmed leukocytoclastic vasculitis. A final diagnosis of Henoch Schoenlein purpura (HSP) was reached based on EULAR Criteria. He was treated with tapering doses of prednisolone, hydroxychloroquine and bed rest with limb elevation. All symptoms and lesions gradually resolved. Various sub-types of cutaneous small vessel vasculitis may mimic each other, warranting a meticulous evaluation. Adult onset HSP though rare must be considered in the differential diagnosis of LCV, which might be the presenting manifestation of an underlying connective tissue disease. Hence long-term follow-up with stringent clinical and laboratory monitoring is recommended.</p>

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Section: Discussionmentioning

confidence: 49%

The enigma of adult onset Henoch Schoenlein purpura and leucocytoclastic Vasculits: a case report

et al. 2021

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“…There is high mortality of up to 30% related to Candidial infections [4,11]. There have been cases found to have invasive candidiasis resulting in poor outcomes or death discovered on autopsy [12,13]. In our patient, the most considerable cause of his expiration was fungemia due to colovesicular fistula likely resulting in septic shock along with his comorbidities.…”

Section: Discussionmentioning

confidence: 68%

Colovesicular fistula from Candida dubliniensis in an immunocompetent resulting in poor outcome

Rizkalla

Ottombrino

Malik

2020

Journal of Community Hospital Internal Medicine Perspectives

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“…On the other hand, cases related to invasive infection by Candida sp. have been described, and although there are few reports in the literature [ 27 , 28 ], it has been observed mainly in patients with a history of diabetes mellitus [ 29 ], immunosuppression due to renal transplantation [ 30 ], and the use of corticosteroids to treat rheumatic diseases [ 28 – 31 ]. Mortality in these cases has been more than 65%, with only 3 reports indicating a good outcome, in young patients [ 27 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

Sudden Esophageal Necrosis and Mediastinitis Associated with Invasive Candidiasis: A Case Report

et al. 2021

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Patient: Male, 35-year-old Final Diagnosis: Esophageal perforation Symptoms: Emesis Medication:— Clinical Procedure: — Specialty: Critical Care Medicine Objective: Rare disease Background: Esophageal necrosis is a rare entity characterized by the presence of extensive circumferential necrosis of the esophagus. It generally affects older adults who have associated chronic pathologies and has a reported mortality rate of approximately 32%. Most patients with esophageal necrosis have a complex clinical course. Case Report: We present the case of a 37-year-old man with idiopathic chronic renal failure who presented to the Emergency Department with sudden esophageal necrosis and mediastinitis, associated with invasive candidiasis. Diagnosis was challenging owing to the rarity of the condition. The patient required intensive care management and multiple surgical procedures. Conclusions: Esophageal necrosis is an uncommon pathology that can be fatal because of associated complications. Its pathophysiology is unclear, and its treatment is based on the control of local injury and signs and symptoms. Acute esophageal necrosis associated with invasive Candida sp. infection is even more infrequent, with only a few cases reported in the literature.

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Fatal necrotizing Candida esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis

Cited by 9 publications

References 19 publications

The enigma of adult onset Henoch Schoenlein purpura and leucocytoclastic Vasculits: a case report

The enigma of adult onset Henoch Schoenlein purpura and leucocytoclastic Vasculits: a case report

Colovesicular fistula from Candida dubliniensis in an immunocompetent resulting in poor outcome

Sudden Esophageal Necrosis and Mediastinitis Associated with Invasive Candidiasis: A Case Report

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