Platelet-rich plasma and subcision act synergistically to improve the appearance of acne scars.

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Introduction: Syringomas are benign eccrine sweat duct tumors. They are typically found in young females predominantly over cheeks and lower eyelids. Rare sites for this tumour include the vulva, palm, soles and penis. Objective: To report a case of syringomas of the vulva which is a rare site for this tumour. Case report: We report a 52-year-old woman presenting with a 30-year history of multiple asymptomatic flesh-coloured non-tender papular lesions of the labia majora. Dermoscopy showed multiple glittering yellow whitish structures in clusters over fading pink background with cobble-stone appearance. Histopathological examination led to the diagnosis of vulvar syringomas. The lesions were treated with intralesional radiofrequency cautery. Conclusions:The vulva is a rare location of syringoma. Dermoscopy may be helpful in establishing early diagnosis and avoiding excessive surgical interventions.

<p class="abstract"><strong>Background:</strong> Platelet rich plasma (PRP) helps tissue re-modulation by its growth factors (GFs)– platelet derived growth factor (PDGF), transforming growth factor (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF-2), insulin-like growth factor (IGF). These GFs aid healing by attracting undifferentiated stem cells into newly formed matrix and triggering cell division; by promoting capillary growth and by attracting macrophages to improve tissue healing and regeneration.<strong> </strong>The aims and objectives of the study were to assess reduction in wound size of chronic non-healing ulcers by autologous platelet rich plasma and to evaluate the safety of autologous platelet rich plasma in treatment of chronic non healing ulcers.</p><p class="abstract"><strong>Methods:</strong> This was an experimental study conducted on ten patients of chronic non-healing ulcers of varied etiology. Autologous PRP was freshly prepared using 10 ml of patient’s own blood by differential centrifugation process and injected at the margins and base of each ulcer. Four such sittings were administered at weekly intervals for four weeks with a post-treatment follow-up period of one month. Total duration of our study was 8 weeks. Objective assessment of ulcer size was done using centimetre scale and documented by digital photographs.<strong></strong></p><p class="abstract"><strong>Results:</strong> While 40% of chronic ulcers healed completely, the remaining 60% cases showed signs of healing at the end of 8 weeks. Mean improvement in ulcer size was 69.38% over a period of 8 weeks. No side effect was encountered in any of our cases.</p><p><strong>Conclusions:</strong> Platelet rich plasma hastened the healing process of chronic non-healing ulcers. Being autologous, it has rare chances of hypersensitivity reactions. </p>

Background: Hirsutism is defined as excess terminal hair growth over androgen-dependent areas in women. It may cause significant social and psychological stigma with a negative impact on the quality of life. However, there is a dearth of data regarding this important parameter from the Indian sub-continent. Objectives: A cross-sectional study was performed to elucidate the quality of life of women with hirsutism using the dermatology life quality index (DLQI). Methods: The severity of hirsutism was graded by modified Ferriman-Gallwey Score (F-G score) and correlated with quality of life by employing self-administered questionnaires of DLQI. Results: Of 40 women with hirsutism (mean DLQI score 5.55 ± 1.501), 3% demonstrated no effect, 52% small effect, and 45% moderate effect. Among domains, “symptoms and feelings” had the highest mean DLQI. Moreover, F-G score and DLQI had a weak positive but insignificant correlation. There was no significant correlation between DLQI and variables like age, marital status, occupation, and polycystic ovarian syndrome (PCOS). Conclusions: Hirsutism had a small to moderate impact on the quality of life, with symptoms and feelings as the most affected domain.