Fatal neurosarcoidosis induced by interferon alpha treatment in chronic hepatitis C

Benzagmout, Mohammed; Oudghiri, Bouchra; Boujraf, Saïd; Chakour, Khalid; Chaoui, Mohamed El Faïz

doi:10.4103/0028-3886.73751

Cited by 1 publication

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, most cases resolve spontaneously after drug discontinuation. Nevertheless, we recommend aggressive treatment of neurologic, ocular, cardiac and renal sarcoidosis or hypercalcemia, because death [30,31], severe loss of vision, fatal arrhythmias, or insidious renal damage may ensue without therapy. …”

Section: Discussionmentioning

confidence: 99%

Two Cases of Interferon-Alpha-Induced Sarcoidosis Koebnerized along Venous Drainage Lines: New Pathogenic Insights and Review of the Literature of Interferon-Induced Sarcoidosis

Buss¹,

Cattin

Spring

et al. 2013

Dermatology

View full text Add to dashboard Cite

Sarcoidosis is a systemic granulomatous disorder of unknown origin commonly affecting the lung, the lymphoid system and the skin. We report here two cases of cutaneous sarcoidosis in two former intravenous drug users following interferon (IFN)-α and ribavirin therapy for chronic hepatitis C. Both patients developed skin sarcoidosis along venous drainage lines of both forearms, coinciding with the areas of prior drug injections. The unique distribution of the skin lesions suggests that tissue damage induced by repeated percutaneous drug injections represents a trigger for the local skin manifestation of sarcoidosis. Interestingly, skin damage was recently found to induce the local expression IFN-α, a well-known trigger of sarcoidosis in predisposed individuals. Here we review the literature on sarcoidosis elicited in the context of IFN-α therapy and propose a new link between the endogenous expression of IFN-α and the induction of disease manifestations in injured skin.

show abstract

Section: Discussionmentioning

confidence: 99%