Fatal Sepsis from Blood Contaminated with Yersinia Enterocolitica: A Case Report

Ps, Collins; Youkey,; Gj, Collins; Jm, Salander; Bm, Elliott; Hj, Donohue; Nm, Rich

doi:10.1093/milmed/150.12.689

Cited by 16 publications

(3 citation statements)

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“…Bacteria found in transfusion‐associated sepsis with RBC units have involved psychrophiles, which are capable of growth at temperatures of 1 to 4°C for up to 42 days and have been found to proliferate at low temperatures to more than 10 5 CFUs per mL 1,5‐9 . Yersinia enterocolitica is the most frequently implicated psychrophilic organism with 21 transfusion‐related cases reported between 1987 and 1997, of which 12 resulted in fatality 5‐7,9 . Other known psychrophiles include Listeria monocytogenes , Pseudomonas sp., Enterobacter sp., and Serratia sp 8,10,11 .…”

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confidence: 99%

Detection of bacteria in stored red cell products using a culture‐based bacterial detection system

Chen

Holme

et al. 2008

Transfusion

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With incubation of eBDS pouches for 48 and 72 hours, 100 percent detection was obtained in 884 samples with bacterial levels of at least 1 CFU per mL, and no false-positive samples were obtained. Based on the bacterial growth patterns, RBC units may be sampled 1 to 3 days after collection for optimal efficacy and read after 48 to 72 hours of incubation of the eBDS sample pouches at 35 degrees C. The Pall eBDS is suited for detection of typical bacterial contaminants in fresh and stored RBCs.

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confidence: 99%

Detection of bacteria in stored red cell products using a culture‐based bacterial detection system

Chen

Holme

et al. 2008

Transfusion

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“…Septisch-toxische Reaktionen nach Transfusion von Yersinia-kontaminiertem Blut werden in der englischsprachigen Literatur mehrfach erwähnt (1)(2)(3)(4)(5)9). Unsere Kasuistik belegt den ersten derartigen Fall im deutschen Sprachraum.…”

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Transfusions-induzierte Yersinia-Sepsis

Bach

Böhrer²

2008

Dtsch med Wochenschr

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After a primary operation for renal artery stenosis a 48-year-old woman had to be re-operated twice for renewed arterial stenosis and retroperitoneal bleeding. The patient's respiratory and cardiovascular functions were stable two days after the second operation and renal function was recovering. But because of suspected renewed bleeding a transfusion with erythrocyte concentrate was begun. Fifteen minutes later the patient started to shiver and this was followed by signs of cardiocirculatory decompensation under the picture of a septic-toxic shock. Laboratory tests did not indicate a haemolytic transfusion reaction. Controlled mechanical ventilation and circulatory drug support were required over the next two days, renewed anuria persisting for longer than a week. Microbiological tests of the erythrocyte concentrate demonstrated Yersinia enterocolitica, serotype 03. Questioning of the blood donor revealed a mild gastroenteritis at the time of donation. This case underlines the need of excluding donors, if only temporarily, when there is even slight suspicion of a Yersinia infection.

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“…Since 1979, there have been 17 reported cases (11 fatalities) of gram-negative bacteremia associated with the use of whole blood or packed erythrocytes (PRBCs) (2. 5,6,9,12,19,21,23,24,26,27); Pseidlononasfluorescens. P. putida, Yersinia enlterocolitic(l, and Canipylobacterjejuni have been implicated.…”

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Growth and endotoxin production of Yersinia enterocolitica and Enterobacter agglomerans in packed erythrocytes

et al. 1989

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Since 1987, the Centers for Disease Control investigated six cases of transfusion-associated sepsis. All six patients developed septic shock after receiving units of packed erythrocytes (PRBCs) contaminated with Yersinia enterocolitica (five patients) and Enterobacter agglomerans (one patient); three of the blood recipients died. We studied the growth and endotoxin production of Y. enterocolitica and E. agglomerans in units of PRBCs stored at 4 degrees C for 60 days. When PRBCs were inoculated with 0.1 to 1.0 CFU of these organisms per ml, both Y. enterocolitica and E. agglomerans entered log-phase growth 2 to 3 weeks after inoculation; generation times were 15 and 22 h, respectively. Endotoxin was first detected at 3 weeks following inoculation, and the concentration paralleled the log phase of growth of the strains tested. These data show that prolonged storage of PRBCs at 4 degrees C provides conditions that allow these two organisms to grow and subsequently produce high concentrations of endotoxin.

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Fatal Sepsis from Blood Contaminated with Yersinia Enterocolitica: A Case Report

Cited by 16 publications

References 0 publications

Detection of bacteria in stored red cell products using a culture‐based bacterial detection system

Detection of bacteria in stored red cell products using a culture‐based bacterial detection system

Transfusions-induzierte Yersinia-Sepsis

Growth and endotoxin production of Yersinia enterocolitica and Enterobacter agglomerans in packed erythrocytes

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