Fate and Effects of the Surfactant Sodium Dodecyl Sulfate

Corynebacterium glutamicum σ E is involved in responses to cell surface stresses and its activity is controlled by the anti-σ factor CseE

“…Functions of sigE and cseE the oxidative stress response, thus inducing genes associated with thioredoxin, glutathione and glutaredoxin (Nickerson & Aspedon, 1992;Singer & Tjeerdema, 1993;Sirisattha et al, 2004). However, this does not appear to be the case for the sigE gene of C. glutamicum, as the C. glutamicum sigE mutant did not evidence sensitivity to thiol-oxidative agents, including diamide.…”

Toxic masking and synergistic modulation of the estrogenic activity of chemical mixtures in a yeast estrogen screen (YES)

“…In an independent parallel study of a different mixture of five (xeno)estrogens in the presence of LAS (alkyl chain length not specified), the same phenomenon was observed in both the original version of the YES assay and an in vivo assay detecting estrogen-dependent vitellogenin induction in fish (Harris et al 2009). In the YES, this might be the result of increased cell membrane permeability, an effect particularly well studied for structurally similar surfactants such as sodium dodecyl sulphate (SDS) (Singer and Tjerdema 1993). Accelerated uptake of estrogens into the yeast cells and potentially also enhanced release of ß-gal into the assay medium might be the consequence.…”

Surfactants and experimental irritant contact dermatitis

“…The surfaceactive nature of SLS makes it useful in diverse applications: as an ingredient in many consumer products, as an aid in manufacturing processes, and as a biological research tool. All of these take advantage of its ability to solubilize fats and oils, lower the surface tension of aqueous solutions, or form microemulsions (8).…”