Fate of carbamazepine, its metabolites, and lamotrigine in soils irrigated with reclaimed wastewater: Sorption, leaching and plant uptake

Paz, Anat; Tadmor, Galit; Malchi, Tomer; Blotevogel, Jens; Borch, Thomas; Polubesova, Tamara; Chefetz, Benny

doi:10.1016/j.chemosphere.2016.06.048

Cited by 113 publications

(78 citation statements)

References 48 publications

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“…Analyte recoveries were 50-105 % and MQLs were 0.25-23 ng g -1 demonstrating the success of the developed protocol. Similar methodologies have since been applied to determine TOrC levels in soil [13][14][15]. However these methods are unable to assess the enantiomeric composition of chiral TOrCs.…”

Section: Introductionmentioning

confidence: 99%

Multi-residue analysis of chiral and achiral trace organic contaminants in soil by accelerated solvent extraction and enantioselective liquid chromatography tandem–mass spectrometry

Petrie

Mrazova

Kasprzyk-Hordern

et al. 2018

Journal of Chromatography A

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Reported here is the first analytical methodology for the enantiomeric determination of chiral trace organic contaminants (TOrCs) in soil. Direct enantioselective separations were achieved on a Chirobiotic V2 column operated in polar ionic mode. Initial screening of vancomycin stationary phases found Chirobiotic V2 better suited for multi-residue separation of chiral TOrCs than Chirobiotic V due to differences in the ligand linkage chemistry. Simultaneous enantioseparation of beta-blockers, beta-agonists, anti-depressants, anti-histamines and stimulants was achieved for the first time. This included the first separation of chlorpheniramine enantiomers with a method suitable for environmental analysis (i.e., coupled to MS). Investigation of mobile phase composition found the concentration of liophilic ions had the greatest influence on enantioseparations and of most importance during method development. The optimized method achieved simultaneous separation of salbutamol, propranolol, atenolol, amphetamine, chlorpheniramine and fluoxetine enantiomers with satisfactory resolution (>1.0). For completeness, such methods also need to support analysis of achiral TOrCs. Therefore three achiral TOrCs (carbamazepine, carbamazepine 10,11 epoxide and triclocarban) were included to demonstrate the methods suitability. Method recoveries for all analytes ranged from 76 to 122% with method quantitation limits (MQLs) <1 ng g. Application of the method to soil microcosm studies revealed stereoselective degradation of chiral TOrCs for the first time. For example, S(+)-amphetamine degraded at a faster rate than its corresponding enantiomer leading to an enrichment of R(-)-amphetamine. Therefore to better understand the risk posed from TOrCs on the terrestrial environment, chiral species need profiled at the enantiomeric level. This can now be addressed using the proposed methodology whilst simultaneously profiling achiral TOrCs.

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Section: Introductionmentioning

confidence: 99%

Multi-residue analysis of chiral and achiral trace organic contaminants in soil by accelerated solvent extraction and enantioselective liquid chromatography tandem–mass spectrometry

Petrie

Mrazova

Kasprzyk-Hordern

et al. 2018

Journal of Chromatography A

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“…The use of both treated and untreated reclaimed wastewater and biosolids in agriculture is a widely adopted practice in countries suffering from water shortages such as Mexico, Israel, Australia and Southern Europe. (Asano et al 2007;Pedrero et al 2010;Dalkmann et al 2012;Lees et al 2016) Further, crops are grown on agricultural soils and cattle producing meat and milk are grazing on grasslands that have been amended with sludge-based biosolids and/or reclaimed wastewater, which poses a potential risk of indirect human exposure via these products (Mohapatra et al 2016;Paz et al 2016;Kinney et al 2006a), which was previously demonstrated (Mottaleb et al 2016;Franklin et al 2016;Malchi et al 2014).…”

Section: Why a New Prioritization Framework Is Neededmentioning

confidence: 99%

Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticals

Burns

Carter

Snape

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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Pharmaceuticals are ubiquitous in the natural environment with concentrations expected to rise as human population increases. Environmental risk assessments are available for a small portion of pharmaceuticals in use, raising concerns over the potential risks posed by other drugs that have little or no data. With >1900 active pharmaceutical ingredients in use, it would be a major task to test all of the compounds with little or no data. Desk-based prioritization studies provide a potential solution by identifying those substances that are likely to pose the greatest risk to the environment and which, therefore, need to be considered a priority for further study. The aim of this review was to (1) provide an overview of different prioritization exercises performed for pharmaceuticals in the environment and the results obtained; and (2) propose a new holistic risk-based prioritization framework for drugs in the environment. The suggested models to underpin this framework are discussed in terms of validity and applicability. The availability of data required to run the models was assessed and data gaps identified. The implementation of this framework may harmonize pharmaceutical prioritization efforts and ensure that, in the future, experimental resources are focused on molecules, endpoints, and environmental compartments that are biologically relevant.

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“…CBZ is also one of the most studied PhACs in soils, with many researches trying to understand its behavior (including the interactions with organic materials) in several types of soils (Stein, Ramil, Fink, Sander, & Ternes, 2008;Navon, Hernandez-Ruiz, Chorover, & Chefetz, 2011;Fenet et al, 2012;Foolad, Hu, Tran, & Ong, 2016;Paz et al, 2016). CBZ has a lower sorption affinity and a higher diffusion in soils compared to the parent compounds, EP-CBZ and DiOH-CBZ, and it can be easily transported from soil surfaces to aquifers (Paz et al, 2016). In fact, similar results were obtained when treated wastewater was used for the irrigation of soils and recharging of artificial aquifers (Fenet et al, 2012).…”

Section: Anticonvulsantsmentioning

confidence: 99%

Environmental impact and biological removal processes of pharmaceutically active compounds: The particular case of sulfonamides, anticonvulsants and steroid estrogens

Leal

Mesquita

Amaral

et al. 2019

Critical Reviews in Environmental Science and Technology

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Pharmaceutically active compounds (PhACs) have recently received wide attention in the scientific community due to their extensive consumption for human health and consequent discharge to the environment. Release of PhACs into the environment, even in trace amounts, can cause serious environmental damage. This has become a major concern and their removal from water sources is a priority. Although a few PhACs are efficiently removed in wastewater treatment plants (WWTPs), others remain recalcitrant, and their release is causing damage. In this review, the current state of the art on the biological removal processes of sulfonamide sulfamethoxazole (SMX), the anticonvulsant carbamazepine (CBZ), and steroid estrogens 17b-estradiol (E2) and 17a-ethinylestradiol (EE2) are discussed, along with their environmental impact. Other systems beyond activated sludge, such as membrane bioreactors, enzymatic membrane reactors, fungi treatments and hybrid systems are also becoming of major interest and are being evaluated for the removal of these compounds. Future perspectives are addressed.

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Fate of carbamazepine, its metabolites, and lamotrigine in soils irrigated with reclaimed wastewater: Sorption, leaching and plant uptake

Cited by 113 publications

References 48 publications

Multi-residue analysis of chiral and achiral trace organic contaminants in soil by accelerated solvent extraction and enantioselective liquid chromatography tandem–mass spectrometry

Multi-residue analysis of chiral and achiral trace organic contaminants in soil by accelerated solvent extraction and enantioselective liquid chromatography tandem–mass spectrometry

Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticals

Environmental impact and biological removal processes of pharmaceutically active compounds: The particular case of sulfonamides, anticonvulsants and steroid estrogens

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