Fate of new three anti-influenza drugs and one prodrug in the water environment

Azuma, Takashi; Ishida, Mao; Hisamatsu, Kanae; Yunoki, Ayami; Otomo, Kana; Kunitou, Mari; Shimizu, Mai; Hosomaru, Kaori; Mikata, Shiori; Mino, Yoshiki

doi:10.1016/j.chemosphere.2016.11.102

Cited by 59 publications

(14 citation statements)

References 57 publications

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“…4 ); antiviral drugs have relatively small Log K ow of -0.3 ± 0.3 (mean ± standard error), suggesting a hydrophilic nature. Azuma et al (2017) evaluated the transport of a set of antiviral drugs by studying their photodegradation, biodegradation, and sorption behaviours in a river for a period of 9 months ( Azuma et al, 2017 ). Except for favipiravir, laninamivir, and laninamivir octanoate, most of the studied antivirals were found to be persistent and could travel from upstream to downstream in chemically unchanged form.…”

Section: Antiviral Drugs: Environmental Occurrence and Potential Ecotmentioning

confidence: 99%

“…Except for favipiravir, laninamivir, and laninamivir octanoate, most of the studied antivirals were found to be persistent and could travel from upstream to downstream in chemically unchanged form. While the majority of antivirals are resistant to photodegradation, favipiravir, which is under clinical trial against SARS-CoV-2, is reported to be removed through photodegradation ( Azuma et al, 2017 ). Most of these antiviral drugs were weakly adsorbed to sediment and sludge samples, indicating removal via sorption is not the primary removal mechanism.…”

Section: Antiviral Drugs: Environmental Occurrence and Potential Ecotmentioning

confidence: 99%

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A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major sources of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.

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Section: Antiviral Drugs: Environmental Occurrence and Potential Ecotmentioning

confidence: 99%

Section: Antiviral Drugs: Environmental Occurrence and Potential Ecotmentioning

confidence: 99%

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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“…The most frequently used assays have been developed on HPLC with a LLOQ in the region of 100-1000ng/mL [17, 20]. Other methods have been developed for LC-MS/MS providing increased sensitivity in comparison to HPLC, with LLOQ in the region of 0.5-2000 ng/mL [21, 22]. In addition to greater sensitivity, the assay presented here demonstrates greater flexibility when applied to the analysis of a diverse array matrices relevant to the further exploration of FAV as a SARS-CoV-2 therapeutic.…”

Section: Discussionmentioning

confidence: 99%

“…While LC-MS/MS methods have been published they are lacking in validation in relevant biological matrices. Previous studies have examined FAV concentrations in an in vitro model of zika infection (samples were cell culture media, Dulbecco’s modified Eagle’s Medium) and FAV contamination of river environment (river and sewage water samples were analysed) [21, 22].…”

Section: Introductionmentioning

confidence: 99%

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir

Curley

Neary

Arshad

et al. 2021

Preprint

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Favipiravir (FAV; T-705) has been approved for use as an anti-influenza therapeutic and has reports against a wide range of viruses (e.g., Ebola virus, rabies and norovirus). Most recently FAV has been reported to demonstrate activity against SARS-CoV-2. Repurposing opportunities have been intensively studied with only limited success to date. If successful, repurposing will allow interventions to become more rapidly available than development of new chemical entities. Pre-clinical and clinical investigations of FAV require robust, reproducible and sensitive bioanalytical assay. Here, a liquid chromatography tandem mass spectrometry assay is presented which was linear from 0.78-200 ng/mL Accuracy and precision ranged between 89% and 110%, 101% and 106%, respectively. The presented assay here has applications in both pre-clinical and clinical research and may be used to facilitate further investigations into the application of FAV against SARS-CoV-2.

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“…Experimental sorption of the target anticancer drugs onto the river sediments was done separately by following the procedure as described previously [56][57][58] as well as OECD guideline No. 106 [59].…”

Section: Estimation Of Sorption Distribution Coefficient (Logk D ) Anmentioning

confidence: 99%

Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan

Azuma

2018

Applied Sciences

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This article reviews the pollution status of anticancer drugs present in the Yodo River basin located in the Kansai district of Japan, covering both the soluble and insoluble (adsorbed on the river sediments and suspended solids) levels. Procedures ranging from sampling in the field and instrumental analytical methods to the data processing for mass balance estimation of the target basin are also described. All anticancer drugs concerned with this article were detected in sewage and river waters, where the presence of bicalutamide (BLT) was identified at considerably high concentrations (maximum 254 ng/L in the main stream, 151 ng/L in tributaries, and 1032 ng/L in sewage treatment plant (STP) effluents). In addition, sorption distribution coefficient (logKd) values showed a tendency to become higher in the silty sediments at Suita Bridge than in the sandy sediments at Hirakata Bridge; these trends were supported by the results of the laboratory-scale sorption experiment. STPs were concluded to be the main sources of the anticancer drug load in the river, and a mass flux evaluation revealed that the effect of attenuation in the river environment was small. The effectiveness of ozonation in the sewage treatment process for removal of these anticancer drugs was further confirmed. The present article should be of value for facilitating the environmental risk assessment of a wide range of drugs in a broader geographical area.

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Fate of new three anti-influenza drugs and one prodrug in the water environment

Cited by 59 publications

References 57 publications

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir

Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan

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