Abstract:Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, na… Show more
“…5 . A combination of magnesium along with vitamins having antioxidant properties has been used to treat noise-induced hearing loss (NIHL) in animals, which is assumed to scavenge oxidative radicals produced due to trauma (le Prell et al 2011 ; Eroglu and Harrison 2013 ; Álvarez et al 2014 ; Maurya et al 2021 ). Fig.…”
Humans being unable to synthesize beta-carotene, the provitamin A, depend on external sources as its supplement. Health benefits and dietary requirements of beta-carotene are interrelated. This orange-red coloured pigment has been enormously examined for its capacity to alleviate several chronic diseases including various types of cancer, cystic fibrosis, as well as COVID-19. However, this class of phytoconstituents has witnessed a broad research gap due to several twin conclusions that have been reported. Natural sources for these compounds along with their extraction methods have been mentioned. The current communication aims at contributing to the global scientific literature on beta-carotene’s application in prevention and treatment of lifestyle diseases.
Graphical abstract
“…5 . A combination of magnesium along with vitamins having antioxidant properties has been used to treat noise-induced hearing loss (NIHL) in animals, which is assumed to scavenge oxidative radicals produced due to trauma (le Prell et al 2011 ; Eroglu and Harrison 2013 ; Álvarez et al 2014 ; Maurya et al 2021 ). Fig.…”
Humans being unable to synthesize beta-carotene, the provitamin A, depend on external sources as its supplement. Health benefits and dietary requirements of beta-carotene are interrelated. This orange-red coloured pigment has been enormously examined for its capacity to alleviate several chronic diseases including various types of cancer, cystic fibrosis, as well as COVID-19. However, this class of phytoconstituents has witnessed a broad research gap due to several twin conclusions that have been reported. Natural sources for these compounds along with their extraction methods have been mentioned. The current communication aims at contributing to the global scientific literature on beta-carotene’s application in prevention and treatment of lifestyle diseases.
Graphical abstract
“…Overall, the particle size of a delivery system must be optimized depending on the nature of the food matrix (especially the expected appearance, texture, and shelf life), as well as the required functional attributes (such as controlled release or bioavailability). There may be certain kinds of delivery systems that are more suitable for specific applications (Maurya, Bashir et al, 2020;Maurya et al, 2021). Such as, a microgel may be more suitable for fortifying jelly-like structures (like gummies), whereas a nanoemulsion may be more suitable for application in low-viscosity beverages (like fortified water or soft drinks) (McClements, 2018a(McClements, , 2018c.…”
Section: Particle Sizementioning
confidence: 99%
“…One of the most effective strategies for increasing the bioaccessibility and bioavailability of oil-soluble bioactive substances is to utilize colloidal delivery systems (Bazile, 2014;Maurya et al, 2022;McClements, 2020). Colloidal particles have been fabricated from a wide range of synthetic and natural materials for this purpose, using a broad spectrum of fabrication technologies (Glowka et al, 2019;Ramalho et al, 2017).…”
Over the past few decades, vitamin D deficiency has been recognized as a serious global public health challenge. The World Health Organization has recommended fortification of foods with vitamin D, but this is often challenging because of its low water solubility, poor chemical stability, and low bioavailability. Studies have shown that these challenges can be overcome by encapsulating vitamin D within well‐designed delivery systems containing nanoscale or microscale particles. The characteristics of these particles, such as their composition, size, structure, interfacial properties, and charge, can be controlled to attain desired functionality for specific applications. Recently, there has been great interest in the design, production, and application of vitamin‐D loaded delivery systems. Many of the delivery systems reported in the literature are unsuitable for widespread application due to the complexity and high costs of the processing operations required to fabricate them, or because they are incompatible with food matrices. In this article, the concept of “fortification by design” is introduced, which involves a systematic approach to the design, production, and testing of colloidal delivery systems for the encapsulation and fortification of oil‐soluble vitamins, using vitamin D as a model. Initially, the challenges associated with the incorporation of vitamin D into foods and beverages are reviewed. The fortification by design concept is then described, which involves several steps: (i) selection of appropriate vitamin D form; (ii) selection of appropriate food matrix; (iii) identification of appropriate delivery system; (iv) identification of appropriate production method; (vii) establishment of appropriate testing procedures; and (viii) system optimization.
“…β-carotene, a precursor to the synthesis of vitamin A, has several health benefits, such as anticancer and antioxidant properties and cardiovascular disease prevention [ 1 , 2 ]. However, β-carotene is difficult to dissolve in water and is sensitive to light, heat, and oxygen, which results in its low bioaccessibility [ 3 ].…”
The β-carotene emulsion system using high-acyl gellan gum (HA) as an emulsifier was fabricated and systematically studied. The stability and stabilizing mechanism of the emulsion using medium-chain triglyceride as oil phase with a water-oil mass ratio of 9:1 under different physicochemical conditions of heat, pH, and ions were investigated by analyzing mean particle size (MPS), emulsion yield (EY), and dynamic stability. The effects of the HA-β-carotene emulsion system on the bioaccessibility of β-carotene in vitro were conducted. During the simulated oral digestion stage (SODP) and simulated gastric digestion stage (SGDP), the emulsion systems stabilized with different HA contents showed good stability, and the changes of MPS and zeta potential (ZP) were within 2.5 μm and 3.0 mV, respectively. After entering the simulated intestinal digestion phase (SIDP), β-carotene was released from oil droplets and formed micelles with bile salts, phospholipids, etc. HA-β-carotene emulsion can enhance the release rate of free fatty acid (FFA), which ultimately affects the β-carotene bioaccessibility. These results indicate that HA can be used to prepare carotene emulsion and improve its bioavailability. The study provides a reference for the application of HA as a natural emulsifier and the delivery of β-carotene.
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