Father to child transmission of human immunodeficiency virus disease while sero-discordant status of the mother is maintained

Sankaranantham, Murugan; Anburajan, Rajanayagam

doi:10.4103/0253-7184.112945

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Некоторые исследователи предполагают, что дети были инфицированы при контакте с пораженными участками кожи отцов [69]. Противоположная точка зрения заключается в том, что сперматозоиды являются переносчиками ВИЧ при оплодотворении [70]. Статья W. D. Cardona Maya, M. T. Ru geles, опубликованная в журнале AIDS Research and Human Retroviruses, так и называется: «Передача ВИЧ от отца к ребенку: не забывайте о роли сперматозоидов как вектора» ("Father-to-child HIV transmission: do not forget sperm cells as vectors") [71].…”

Section: вирус иммунодефицита человекаunclassified

Viral infection of sperm. Part 2. Human herpes viruses, human immunodeficiency virus, hepatitis C virus, Zika virus (review)

Брагина

2021

Androl. genit. hir.

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Intragametal viral infection of spermatozoa can cause true vertical transmission of viruses through germ cells. Currently, human immunodeficiency virus, hepatitis C viruses, herpes simplex virus, cytomegalovirus, Zika virus have been detected in spermatozoa. The possibility of vertical transmission of human immunodeficiency virus, cytomegalovirus, herpes simplex virus and Zika virus has been proven.Intragametal infection of spermatozoa with viruses of the herpes group leads to abnormalities in the development of the embryo and can cause spontaneous abortions both during natural conception and when using assisted reproductive technologies.The development of adequate methods for diagnosing an intragametal spermatozoa virus infection will make it possible to find out, at least in some patients, the cause of infertility and pregnancy abnormalities and apply appropriate antiviral therapy in preparation for natural conception or the use of assisted reproductive technologies.

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Section: вирус иммунодефицита человекаunclassified

Viral infection of sperm. Part 2. Human herpes viruses, human immunodeficiency virus, hepatitis C virus, Zika virus (review)

Брагина

2021

Androl. genit. hir.

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“…1 In another unusual case, a father apparently infected one of his three children, a 5year-old boy, while the mother had not been infected. 2 Several modes of non-MTC HIV transmission have been reported, including unsafe needle practices (nosocomial), 3 surrogate breastfeeding, 4 premastication of food, 5 and sexual abuse. 6 Phylogenetic analysis can aid in source attribution in such cases.…”

Section: Introductionmentioning

confidence: 99%

Accidental Father-to-Son HIV-1 Transmission During the Seroconversion Period

Ezeonwumelu

Bártolo

Martin

et al. 2018

AIDS Research and Human Retroviruses

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A 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about 4 years after the child's birth. Partial segments of three HIV-1 genes (gag, pol, and env) were sequenced and maximum likelihood (ML) and Bayesian methods were used to determine direction and estimate date of transmission. Neutralizing antibodies were determined using a single cycle assay. Bayesian trees displayed a paraphyletic-monophyletic topology in all three genomic regions, with the father's host label at the root, which is consistent with father-to-son transmission. ML trees found similar topologies in gag and pol and a monophyletic-monophyletic topology in env. Analysis of the time of the most recent common ancestor of each HIV-1 gene population indicated that the child was infected shortly after the father. Consistent with the infection history, both father and son developed broad and potent HIV-specific neutralizing antibody responses. In conclusion, the direction of transmission implicated the father as the source of transmission. Transmission occurred during the seroconversion period when the father was unaware of the infection and was likely accidental. This case shows how genetic, phylogenetic, and serological data can contribute for the forensic investigation of HIV transmission.

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Father-to-Child HIV Transmission: Do Not Forget Sperm Cells as Vectors

Maya

Rugeles

2019

AIDS Research and Human Retroviruses

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Father to child transmission of human immunodeficiency virus disease while sero-discordant status of the mother is maintained

Cited by 3 publications

References 7 publications

Viral infection of sperm. Part 2. Human herpes viruses, human immunodeficiency virus, hepatitis C virus, Zika virus (review)

Viral infection of sperm. Part 2. Human herpes viruses, human immunodeficiency virus, hepatitis C virus, Zika virus (review)

Accidental Father-to-Son HIV-1 Transmission During the Seroconversion Period

Father-to-Child HIV Transmission: Do Not Forget Sperm Cells as Vectors

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