HIV is a chronic well manageable disease. Highly active antiretroviral therapy improves the quality of life of people living with HIV, but the treatment has to be continued lifelong, as the total cure has not been established. Cost of treatment, drug toxicities, interaction with other drugs and persistence of inflammation and acceleration of the aging process, all put together, warrant an urgent need for a total cure. Even though one case had been proved to be cured, still a practical cure is far beyond the reach. Numerous approaches and strategies had been put forth to achieve a cure; still they are to be proved with human studies. This article reviews the major approaches, recent advances in the venture of HIV cure, and the safety concerns involved.

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Gynecomastia and hypogonadism are not included among the side effects of efavirenz in its drug information even though they had been reported by different authors. Especially they were more common in young adolescent individuals. Here I am reporting a case of Hypogonadism and two cases of gynecomastia among adolescent boys.

HIV transmission through Tattooing is not a common mode of transmission. Tattooing becomes fashion and popular among youngsters throughout the world. A 26 year old man without any history of sexual activities, blood transfusion and IV drug abuse, acquired HIV through tattooing is being reported. Younger generation should be educated and made aware about the risk of transmission of blood-borne diseases is emphasized. HIV Transmission through TattoosMurugan Sankaranantham* Community Care Centre, Tirunelveli, Tamil Nadu, India Transmission of diseases from tattooing may be related to the use of needles that were contaminated with blood from a previously tattooed individual, or the use of contaminated dyes and other material, such as sponges or tissues used to wipe away blood. HIV has been shown to remain infectious in aqueous solutions at room temperature for up to fifteen days and pigmented solutions, because they are relatively inert. A single needle stick injury from an infected host carries with it a 5-30% risk of transmission of hepatitis B (HBV), a 3-7% risk of transmission of hepatitis C (HCV), and a 0.2-0.4% risk of transmission of HIV. As