“…The biocompatibility, especially thrombocompatibility, of Ti can be enhanced by introducing alloy elements [325]. Some publications [326][327][328][329][330][331][332][333][334] provide limited information on the toxic activity of V as an alloy element in the Ti6Al4V alloy, because it was found that V could be regarded as a potentially toxic factor [335,336], which is, however, true only for a considerable concentration of V in a body, due to development of its undesired immunological response, when the freed V ions migrate from the material surface to a soft tissue, binding with proteins [337,338]. Some research on cells implies that Ti6Al4V exhibits high cytotoxicity [307][308][309][310][311]339]; there are reports that V may cause sterile abscesses, and Al may cause scarring, while Ti, Zr, Nb and Ta show good biocompatibility [340].…”