Fatigue due to mild heart failure: effects of Robuvit® in a concept, pilot registry study

Belcaro, Gianni; Cesarone, M. R.; Scipione, Valeria; Scipione, Claudia; Dugall, Mark; Shu, Hu; Hosoi, Morio; Cotellese, Roberto; Olivieri, Nello; Feragalli, Beatrice; Ledda, Andrea

doi:10.23736/s0026-4725.19.05029-1

Cited by 4 publications

(19 citation statements)

References 23 publications

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“…The study authors of this pilot study concluded that Robuvit may aid individuals who present with mild heart failure. 26 Robuvit improves fatigue in postflu convalescence. Ippolito et al revealed the efficacy of supplementation with Robuvit for improving fatigue in medical convalescence, after the postdisease period (3 days without disease) subsequent to an influenza infection.…”

Section: Enhanced Recovery Abilitymentioning

confidence: 98%

“…The reported improved mitochondria regeneration, enhanced ribosomal biogenesis, increased muscle mass, and the elevated antioxidant capacity caused by urolithins give a rational basis for the results of clinical trials with Robuvit, which was shown to accelerate overall energy. 8,[22][23][24] Decreased fatigue symptoms 22,23 and better sleep, 16,23,27 faster recovery after disease 7,[10][11][12]17,19,26 or surgery, 5,14 improved mood, 8,16,27 enhanced erectile function, 22,24 reinforced antioxidant defense mechanisms in periods of stress, 18 or enhanced muscle mass gain after intense exercise 6 are the effects that have been described in diverse clinical studies (Fig. 5).…”

Section: Clinical Effects Of Robuvitmentioning

confidence: 99%

“… Clinical effects of Robuvit. In several clinical studies, Robuvit supplementation was shown to induce better sleep, 16 , 23 , 27 improve sport performance, 6 lower symptoms of chronic fatigue syndrome, 22 , 23 enhance burnout symptoms, 18 improve mood 8 , 16 , 27 and erectile function, 22 , 24 enhance postsurgery 5 , 14 and disease recovery, 7 , 10–12 , 17 , 19 , 26 and increase overall energy. 8 , 22–24 …”

Section: Clinical Effects Of Robuvitmentioning

confidence: 99%

“…For an investigation of Robuvit's potential benefits on mild heart failure, 40 study participants with mild, stable heart failure were recruited. 26 The study participants were either assigned to the group continuing their medications as before or another group supplemented with Robuvit 300 mg/day in addition to their medications over an observational time period of 12 weeks. The ejection fraction in study participants who took Robuvit significantly improved by 7.2% in only 8 weeks, while it did not significantly improve in the control group.…”

Section: Clinical Effects Of Robuvitmentioning

confidence: 99%

“…The ejection fraction in study participants who took Robuvit significantly improved by 7.2% in only 8 weeks, while it did not significantly improve in the control group. 26 This effect could be explained by the ability of Robuvit to stimulate protein production and skeletal muscle growth. Walking distance on a treadmill was significantly extended in the Robuvit-supplemented group compared with the control group.…”

Section: Clinical Effects Of Robuvitmentioning

confidence: 99%

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Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit

Weichmann

Avaltroni

Bürki

2021

Journal of Medicinal Food

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Since ancient times, oak wood polyphenols are consumed concomitantly with beverages that are stored and aged in oak wood barrels. Among these polyphenols are roburins, which belong to the class of ellagitannins and only occur in oak. To date, water-extracted standardized French Quercus robur wood extract, commercially known as Robuvit Ò , has been investigated in 1172 subjects in over 20 published clinical trials. The results of the clinical studies are consistent with reported effects of urolithins regarding increased mitophagy, pointing to enhanced energy capacity. The Robuvit metabolite urolithin A, B, and C levels and the number of urolithin producers were found to be increased after intake of the extract. Mitophagy is a process, which assigns energy inefficient mitochondria to disassembly, followed by reconstruction to new and more efficient replacements. This effect of Robuvit was observed in different study groups. Supplementation of Robuvit is ascribed to aid chronically fatigued or burnt-out individuals to regain higher energy and activity levels. Robuvit has been further shown to improve conditions such as renal insufficiency, liver insufficiency, mild heart failure, posttraumatic stress disorder and fatigue after surgery and facilitate recovery from mild health impairments such as flu or hangover. There are also indications that Robuvit helps improve erectile function and general loss of vigor in elderly men. Ex vivo gene expression experiments using metabolites collected from Robuvit consumers point to increased ribosomal biogenesis in endothelial, neuronal, and keratinocyte cells. Higher ribosome density accelerates the peptide production to meet protein demand, making Robuvit a potential enhancer of physical endurance and performance. A study with recreational athletes, supplemented with Robuvit daily, reported significantly increased performance in triathlon.

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Section: Enhanced Recovery Abilitymentioning

confidence: 98%