Fatigue in Breast Cancer Survivors: Occurrence, Correlates, and Impact on Quality of Life

Bower, Julienne E.; Ganz, Patricia A.; Desmond, Katherine A.; Rowland, Julia H.; Meyerowitz, Beth E.; Belin, Thomas R.

doi:10.1200/jco.2000.18.4.743

Cited by 985 publications

(919 citation statements)

References 22 publications

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“…These results are close to regional and international figures (Hopwood et al, 2007;Waldmann et al, 2007;Jassim and Whitford, 2013). Studies examining the prevalence of fatigue among breast cancer patients found that up to 99% of patients suffer from some degree of fatigue during chemotherapy and/or radiotherapy and that more than 60% of them experience moderate to severe fatigue (Bower et al, 2000;2006). Published studies showed that fatigue predicts psychological impairment in the forms of HADS score, depression score and anxiety score (Vahdaninia et al, 2010).…”

Section: Discussionsupporting

confidence: 81%

“…On the other hand, when compared with regional or international figures (Hopwood et al, 2007;Waldmann et al, 2007;Jassim and Whitford, 2013), the patients' low scores in the physical functioning domain, could not be justified by the age difference (Arndt et al, 2004), the presence of other co-morbidities, or by the prevalence of fatigue (Bower et al, 2000). The study participants' mean age of 50.7 years is similar to the mean age in the Bahraini study (Jassim and Whitford, 2013) and only 5.5% of the Jordanian patients had at least one chronic disease.…”

Section: Discussionmentioning

confidence: 63%

See 1 more Smart Citation

Quality of Life and Psychological Well-Being of Breast Cancer Survivors in Jordan

Abu-Helalah¹,

Al-Hanaqta²,

Alshraideh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 63%

Quality of Life and Psychological Well-Being of Breast Cancer Survivors in Jordan

Abu-Helalah¹,

Al-Hanaqta²,

Alshraideh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Miaskowski and Lee [32], in a study of patients with bone metastasis, found that these patients reported only moderate fatigue but significant sleep disturbance. Several investigators found that fatigue was also related to depression, anxiety, and/or pain in patients undergoing chemotherapy [36,43] and after the end of chemotherapy [9,43]. Three studies examined the relationship between fatigue and reports of sleep disruption before treatment [16,26,34], but no studies examined fatigue and objectively recorded sleep before treatment.…”

Section: Introductionmentioning

confidence: 99%

Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer

Ancoli‐Israel

Liu

Marler

et al. 2005

Support Care Cancer

267

206

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Goals-Previous investigations have shown that women undergoing chemotherapy for breast cancer experience both disturbed sleep and fatigue. However, most of the previous research examined women either during or after chemotherapy. This study examined sleep, fatigue, and circadian rhythms in women with breast cancer before the start of chemotherapy.Patients and methods-Eighty five women with Stages I-IIIA breast cancer who were scheduled to begin adjuvant or neo-adjuvant anthracycline-based chemotherapy participated. Each had sleep/ wake activity recorded with actigraphy for 72 consecutive hours and filled out questionnaires on sleep, fatigue, depression, and functional outcome.Main results-On average, the women slept for about 6 h a night and napped for over an hour during the day. Sleep was reported to be disturbed and fatigue levels were high. Circadian rhythms were robust, but women who were more phase-delayed reported more daily dysfunction (p<0.01). Conclusions-The data from the current study suggest that the women with breast cancer likely experience both disturbed sleep and fatigue before the beginning of chemotherapy. Although their circadian rhythms are robust, breast cancer patients with more delayed rhythms experience more daily dysfunction secondary to fatigue. These data suggest that strategies to improve disturbed sleep and to phase-advance circadian rhythms prior to initiation of chemotherapy may be beneficial in improving daily function in breast cancer patients.

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“…Many studies suggest that fatigue is a common problem experienced by female survivors of breast cancer 6,[9][10][11][12][13][14][15] . Moreover, previous studies have confirmed that breast cancer survivors with increased fatigue rated their quality of life at a lower level [12][13][14]16 .…”

Section: Introductionmentioning

confidence: 99%

Fatigue and quality of life in breast cancer survivors: a comparative study

Kluthcovsky¹,

Urbanetz²

2015

Rev. Bras. Ginecol. Obstet.

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PURPOSE: To assess fatigue and quality of life in disease-free breast cancer survivors in relation to a sample of age-matched women with no cancer history and to explore the relationship between fatigue and quality of life. METHODS: A cross-sectional study was conducted in a sample of 202 consecutive disease-free Brazilian breast cancer survivors, all of whom had completed treatment, treated at 2 large hospitals. The patients were compared to age-matched women with no cancer history attending a primary health care center. The Piper Fatigue Scale-Revised and the World Health Organization Quality of Life Instrument (WHOQOL-BREF) were used to measure the fatigue and quality of life, respectively. Socio-demographic and clinical variables were also obtained. The χ 2 test, generalized linear model, and Spearman correlation coefficient were used for statistical purposes. The adopted level of significance was 5%. RESULTS: Breast cancer survivors experienced significantly greater total and subscale fatigue scores than comparison group (all p-values<0.05). In addition, survivors reported a poorer quality of life in physical (p=0.002), psychological (p=0.03), and social relationships (p=0.03) domains than comparison group. No difference was found for the environmental domain (p=0.08) for both groups. For survivors of breast cancer and for comparison group, the total and subscale fatigue scores were related to lower quality of life (all p-values<0.01). CONCLUSION: The findings of this study highlight the importance of assessing fatigue and quality of life in breast cancer survivors. ResumoOBJETIVO: Avaliar a fadiga e a qualidade de vida de sobreviventes de câncer de mama, livres da doença, em relação a uma amostra de mulheres da mesma idade, sem histórico de câncer, e explorar a relação entre fadiga e qualidade de vida. MÉTODOS: Estudo transversal realizado com uma amostra consecutiva de 202 pacientes brasileiras, sobreviventes de câncer de mama e livres da doença, que haviam completado o tratamento em 2 grandes hospitais. As pacientes foram comparadas com mulheres da mesma idade, sem história de câncer, acompanhadas em uma Unidade Básica de Saúde. A Escala de Fadiga de Piper-Revisada e o World Health Organization Quality of Life Instrument (WHOQOL-BREF) foram usados para avaliar a fadiga e a qualidade de vida, respectivamente. Dados sociodemográficos e clínicos também foram obtidos. O teste do χ 2 , modelo linear generalizado e coeficiente de correlação de Spearman foram utilizados para fins estatísticos. Foi adotado o nível de significância de 5%. RESULTADOS: As sobreviventes de câncer de mama apresentaram significativamente maiores escores de fadiga total e das subescalas do que o grupo controle (todos os valores de p<0,05). Além disso, as sobreviventes relataram pior qualidade de vida nos domínios físico (p=0,002), psicológico (p=0,03) e relações sociais (p=0,03) do que o grupo controle. Nenhuma diferença foi encontrada para o domínio ambiental (p=0,08) entre os 2 grupos. Para as sobreviventes de câncer de mama...

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Fatigue in Breast Cancer Survivors: Occurrence, Correlates, and Impact on Quality of Life

Cited by 985 publications

References 22 publications

Quality of Life and Psychological Well-Being of Breast Cancer Survivors in Jordan

Quality of Life and Psychological Well-Being of Breast Cancer Survivors in Jordan

Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer

Fatigue and quality of life in breast cancer survivors: a comparative study

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