Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer

Ancoli‐Israel, Sonia; Liu, Lianqi; Marler, Matthew; Parker, Barbara A.; Jones, Vicky; Sadler, Georgia Robins; Dimsdale, Joel E.; Cohen-Zion, Mairav; Fiorentino, Lavinia

doi:10.1007/s00520-005-0861-0

Cited by 267 publications

(251 citation statements)

References 36 publications

(49 reference statements)

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…Most recently, Ancoli-Israel and colleagues [28] reported that sleep disorders and fatigue were prevalent in patients with breast cancer prior to the start of chemotherapy. However, while subjective measures of the two symptoms were significantly correlated, no significant correlation was found between subjective measures of fatigue and objective evaluation of sleep (by actigraphy).…”

Section: Objective Measurement Of Sleep Continuitymentioning

confidence: 99%

Cancer-Related Fatigue and Sleep Disorders

et al. 2007

View full text Add to dashboard Cite

Sleep disorders, such as difficulty falling asleep, problems maintaining sleep, poor sleep efficiency, early awakening, and excessive daytime sleepiness, are prevalent in patients with cancer. Such problems can become chronic in some patients, persisting for many months or years after completion of cancer therapy. For patients with cancer, sleep is potentially affected by a variety of factors, including the biochemical changes associated with the process of neoplastic growth and anticancer treatments, and symptoms that frequently accompany cancer, such as pain, fatigue, and depression.Fatigue is highly prevalent and persistent in patients with cancer and cancer survivors. Although cancerrelated fatigue and cancer-related sleep disorders are distinct, a strong interrelationship exists between these symptoms, and a strong possibility exists that they may be reciprocally related. The majority of studies that have assessed both sleep and fatigue in patients with cancer provide evidence supporting a strong correlation between cancer-related fatigue and various sleep parameters, including poor sleep quality, disrupted initiation and maintenance of sleep, nighttime awakening, restless sleep, and excessive daytime sleepiness. This paper reviews the data from these studies with a view toward suggesting further research that could advance our scientific understanding both of potential interrelationships between sleep disturbance and cancer-related fatigue and of clinical interventions to help with both fatigue and sleep disturbance. The Oncologist 2007;12(suppl 1): [35][36][37][38][39][40][41][42]

show abstract

Section: Objective Measurement Of Sleep Continuitymentioning

confidence: 99%

Cancer-Related Fatigue and Sleep Disorders

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Table 1 summarizes the data for 1129 cancer patients for whom actigraphy data were correlated with data from fatigue questionnaires. 13,14,[49][50][51][52][53][54][55][56][57][58][59][60][61] In 2 out of 13 studies, no significant correlation between actigraphy parameters and fatigue was described. 56.61 In the remaining 11 studies, performed in patients with different types of cancer, using different actigraphy devices and different fatigue scales, the degree of fatigue was found to be associated with circadian disruption, poor sleep, or lower daytime physical activity.…”

Section: Correlations Between Objective Circadian Disruption and Subjmentioning

confidence: 99%

Circadian Disruption, Fatigue, and Anorexia Clustering in Advanced Cancer Patients: Implications for Innovative Therapeutic Approaches

et al. 2009

View full text Add to dashboard Cite

A disruption of the circadian timing system, as identified by monitoring of marker biorhythms, is common in cancer patients. The recording of the rest-activity rhythm with a wrist actigraph has been commonly used. This noninvasive monitoring allows a robust estimation of circadian disruption. The authors have previously found that altered patterns of circadian rest-activity rhythms are significantly and independently associated with the severity of fatigue and anorexia in patients with metastatic colorectal cancer. Elevated proinflammatory cytokines could partly account for this circadian disruption and its associated constitutional symptoms. Here, the authors present and discuss the data supporting the hypothesis that circadian disruption is often associated with fatigue and anorexia, which in turn further alter and dampen circadian synchronization, thus, creating a vicious cycle. This body of evidence paves the path for innovative therapeutic approaches targeting the circadian timing system in an effort to diminish constitutional symptoms induced by cancer and some anticancer treatments.

show abstract

“…stage [3,52], treatment [3,11]), physical health/symptoms (e.g. physical health [10,14,53], pain [52,53], vasomotor symptoms [8,54], GU symptoms [11]), fatigue [53,55,56], light exposure [57], and other variables identified as linked with insomnia in the general population (e.g. being widowed/separated [3], lower education [52], poor social support [52], depression/psychological distress [52,53]).…”

Section: Introductionmentioning

confidence: 99%