Fatigue in Multiple Sclerosis

Abstract

The role of the cognitive dimension of fatigue in multiple sclerosis (MS) 1 is supported by working memory impairment in persons with chronic progressive MS 2 and by the contribution of articulatory rehearsal to working memory. 3 These findings prompt the assessment of fatigue in the MS patient 1 by analyzing speech pauses on a time-base. 4

Validation of the Functional Assessment of Chronic Illness Therapy‐Fatigue (FACIT‐F) in patients with inflammatory bowel disease

“…Internal consistency of the FACIT‐F was excellent, with a Crohnbach alpha of 0.94 for UC and 0.95 for CD. This is similar to what has been reported in psoriatic arthritis and other chronic diseases in which the FACIT‐F has been validated 17, 22, 30, 31 …”

“…Fatigue has been found to be an important symptom in patients with several other chronic diseases such as primary billiary cirrhosis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus, sclerosing cholangitis, psoriatic arthritis and multiple sclerosis 10–17 . Many of these diseases, like IBD, are thought to involve an abnormal immune response.…”

The added value of cognition-targeted exercise versus symptom-targeted exercise for multiple sclerosis fatigue: A randomized controlled pilot trial

“…The causes of fatigue in people with MS have not been clearly defined in the research [ 6 ]. Approximately 65% of people with MS reported fatigue-related symptoms as one of the three most bothersome aspects of their symptoms [ 7 ], with a profound side effect on health-related quality of life and daily activity performance [ 8 ]. Fatigue also interfered with daily activities for people with MS, causing numerous troubles in occupational, educational, economic, recreational and family areas, ultimately producing negative outcomes in social and personal communications and mental health outcomes [ 9 ].…”