Fatigue in sarcoidosis: a systematic review

Kleijn, Willemien P. E. De; Vries, Jolanda De; Lower, Elyse E.; Elfferich, Marjon; Baughman, Robert P.; Drent, Marjolein

doi:10.1097/mcp.0b013e32832d0403

Cited by 91 publications

(68 citation statements)

References 30 publications

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“…They were: for FEF 25 No correlation between 6-minute walking distance and FAS score was found either (r = 0.01, p = 0.9) (Fig. 6).…”

Section: Resultsmentioning

confidence: 99%

“…The strength of the quadriceps muscle of the thigh, of the palm muscles, and respiratory muscles was significantly lower in sarcoidosis compared to the control group. A correlation between muscle strength and fatigue was found to be weak in men and strong in the examined women [25]. The research conducted by Spruit showed that that patients complaining of fatigue had lower muscle mass and lower exercise tolerance, compared to healthy subjects [11].…”

Section: Discussionmentioning

confidence: 99%

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Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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Fatigue in patients with inactive sarcoidosis does not correlate with lung ventilation ability or walking distance. Pilot StudyZmęczenie u chorych z nieaktywną sarkoidozą nie koreluje ze zdolnością wentylacyjną płuc oraz z dystansem chodu. Badanie pilotażoweThe work has been conducted under a grant from the Silesian Medical University: project No. KNW-1-025/D/2/0 Abstract Introduction: Fatigue is one of many symptoms reported by patients with sarcoidosis. It is believed that fatigue may be the cause of exercise intolerance and reduced quality of life in patients with sarcoidosis. The purpose of the work was to present the frequency of fatigue prevalence in patients with sarcoidosis and to investigate the correlation between fatigue and the results of pulmonary function tests and walking distance. Material and methods: A total of 74 patients with sarcoidosis in a stable phase of the disease, not treated in the past with glucocorticoids or immunosuppressive drugs, and without indications for treatment at the time of the study were examined. In all patients fatigue evaluation was carried out with the use of the Fatigue Assessment Scale questionnaire (FAS); dyspnoea was assessed with the use of the Medical Research Council scale (MRC). Body Mass Index (BMI), spirometry, and a 6-minute walk test were additionally performed. The control group included 30 healthy volunteers who completed the FAS. Results: In the examined group of patients fatigue was diagnosed in 36 patients (50%), and in 5 (6.94%) -strong fatigue was observed. The remaining 31 (43.06%) patients felt no fatigue. The average value of points obtained by FAS questionnaire in sarcoidosis patients was significantly higher than the respective value in the control group (p = 0.02). A significantly higher number of points by FAS questionnaire was observed in female patients with sarcoidosis (p = 0.04) in comparison to men. No significant statistical correlation between fatigue index FAS and BMI (r = 0.22, p = 0.11), FEV 1 (r = -0.11, p = 0.3), FEV 1 % pred. (r = 0.01, p = 0.9), FVC (r = −0.03, p = 0.77), FEF 25−75 (r = −0.23, p = 0.1) and the distance in the six-minute walk test (6MWT) (r = −0.01, p = 0.9) was observed. However, there was a weak negative correlation between the age of the patients and the FAS index (r = −0.29, p = 0.01). Conclusions: Fatigue in patients with sarcoidosis does not correlate with the results of lung function tests or with walking distance in 6MWT.

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“…They were: for FEF 25 No correlation between 6-minute walking distance and FAS score was found either (r = 0.01, p = 0.9) (Fig. 6).…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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“…Fatigue is an important aspect of sarcoidosis. There have been an increasing number of studies regarding sarcoidosis associated fatigue [63]. There was a correlation between fatigue and 6MWD [45].…”

Section: Quality Of Lifementioning

confidence: 99%

Established and experimental medical therapy of pulmonary sarcoidosis

et al. 2013

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The treatment options for pulmonary sarcoidosis have increased over the past 10 years. As new treatments have been introduced, the best way to assess and compare treatments remains unknown. The goal of this review is to discuss the standard treatments for pulmonary sarcoidosis, including glucocorticoids, and cytotoxic agents, such as methotrexate, azathioprine and leflunomide, and compare them to the newer biological agents, such as infliximab and adalimumab. We also discuss some novel treatments which are currently being evaluated. To compare these different regimens, we look at the measures used to assess response. These include pulmonary function, chest imaging, steroid sparing potential and, more recently, improvements in quality of life measures. While there is, as yet, no standard assessment for response, there is a growing consensus that response to treatment may include improvement of one or more of the following: forced vital capacity, chest imaging and steroid sparing. Several drugs used for pulmonary sarcoidosis have demonstrated improvement in one or more of these measures.

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“…22,24 Initially developed by De Vries et al, 25 it is a well-validated and reliable scale. 22 The questionnaire consists of 2 subscales, 5 questions each on the physical and mental aspect of fatigue. There are 5 answer options ranging from "never" to "always."…”

Section: Fasmentioning

confidence: 99%

“…21 Although there are several studies examining specific putative reasons for elevated fatigue levels in sarcoidosis, many of them are based on relative small sample sizes. 22 Furthermore, the association between comorbidity and fatigue has been mentioned only in case reports. 23 Hence, in the current study, we intended to comprehensively test several factors associated with fatigue in sarcoidosis.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Fatigue in Sarcoidosis

Fleischer¹,

Hinz²,

Brähler³

et al. 2013

Respir Care

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BACKGROUND: Fatigue is a frequent symptom of patients with sarcoidosis. The origin of fatigue associated with sarcoidosis is unclear. The aim of this study was to assess the impact of affected organs, medication, and comorbidity on fatigue related to sarcoidosis. METHOD: In collaboration with the German Sarcoidosis Society, a sample of 1,197 subjects diagnosed with sarcoidosis was examined. The participants completed a questionnaire that contained the Fatigue Assessment Scale and the Multidimensional Fatigue Inventory. RESULTS: In this study, muscles, bones, and nerves were most strongly associated with fatigue. Patients receiving prednisolone showed heightened fatigue levels. However, the association between the duration of prednisolone therapy and fatigue was weak. The concomitant diseases, pulmonary hypertension and sleep apnea, showed the greatest impact elevating fatigue (effect sizes d > 0.50). In the combined regression analysis, comorbidity was the most important predictor of fatigue. CONCLUSIONS: It is important to consider that multiple clinical factors, especially comorbidities, contribute to the high degrees of fatigue in sarcoidosis.

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Fatigue in sarcoidosis: a systematic review

Cited by 91 publications

References 30 publications

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Established and experimental medical therapy of pulmonary sarcoidosis

Factors Associated With Fatigue in Sarcoidosis

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