Fatigue Is Associated With Quality of Life in Sarcoidosis Patients

Abstract

Fatigue is associated with quality of life in sarcoidosis patientsMichielsen, H.J.; Drent, M.; Peros-Golubicic, T.; de Vries, J. Published in: Chest Document version:Publisher's PDF, also known as Version of record Publication date: 2006 Link to publication Citation for published version (APA):Michielsen, H. J., Drent, M., Peros-Golubicic, T., & de Vries, J. (2006). Fatigue is associated with quality of life in sarcoidosis patients. Chest, 130(4), 989-994. General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.-Users may download and print one copy of any publication from the public portal for the purpose of private study or research -You may not further distribute the material or use it for any profit-making activity or commercial gain -You may freely distribute the URL identifying the publication in the public portal Take down policyIf you believe that this document breaches copyright, please contact us providing details, and we will remove access to the work immediately and investigate your claim. Michielsen, PhD; Marjolein Drent, MD, PhD; Tatjana Peros-Golubicic, MD, PhD; and Jolanda De Vries, PhD, MSc Background: Fatigue is one of the core symptoms of sarcoidosis patients. Although it is known that fatigue affects quality of life (QOL) in other patient groups, this relationship has never been studied in sarcoidosis patients using a reliable and valid fatigue scale and a multidimensional QOL instrument. The present cross-sectional study among sarcoidosis patients attempts to gain more insight into this relationship.

Benefits of Physical Training in Sarcoidosis

“…Scores below 22 indicate no fatigue; scores of 22-34 indicate mild-moderate fatigue; and scores of 35 or more indicate extreme fatigue. In sarcoidosis, the FAS has acceptable psychometric properties [28]. The minimal clinically important difference in sarcoidosis is 4 points or a 10% change [29].…”

Physical activity and training in sarcoidosis: review and experience-based recommendations

“…Sarcoidosis-related complaints, including fatigue, may become chronic and affect patients' QoL even after all other signs of disease activity have disappeared; this appears to be unique to sarcoidosis-related fatigue as compared to other inflammatory conditions [36,71]. Physicians generally assess disease severity and progression in sarcoidosis on the basis of socalled 'objective measures' such as pulmonary function tests, chest radiographs, and serologic tests.…”

Inflammation and the Silent Sequelae of Stroke

“…The FAS has been validated in healthy cohorts [71]. FAS scores of 10-21 indicate that the patient is "not tired", scores of 22-34 indicate that the patient is "tired", and scores of [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] indicate that the patient is "very tired" [72]. We evaluated the relationship between the biomarkers of inflammation shown in Fig.…”