Hybrid laminates consist of layers of different materials, which determine the mechanical properties of the laminate itself. Furthermore, the structure and interfacial properties between the layers play a key role regarding the performance under load and therefore need to be investigated in respect to industrial applicability. In this regard, a hybrid laminate comprised of AA6082 aluminum alloy sheets and glass and carbon fiber-reinforced thermoplastic (polyamide 6) is investigated in this study with a focus on the influence of aluminum surface treatment application on tensile and fatigue behavior. Four different aluminum surface treatments are discussed (adhesion promoter, mechanical blasting, phosphating, and anodizing), which were characterized by Laser Scanning Microscopy. After the thermal consolidation of the hybrid laminate under defined pressure, double notch shear tests and tensile tests were performed and correlated to determine the resulting interfacial strength between the aluminum sheet surface and the fiber-reinforced plastic, and its impact on tensile performance. To investigate the performance of the laminate under fatigue load in LCF and HCF regimes, a short-time procedure was applied consisting of resource-efficient instrumented multiple and constant amplitude tests. Digital image correlation, thermography, and hysteresis measurement methods were utilized to gain information about the aluminum surface treatment influence on fatigue damage initiation and development. The results show that fatigue-induced damage initiation, development, and mechanisms differ significantly depending on the applied aluminum surface treatment. The used measurement technologies proved to be suitable for this application and enabled correlations in between, showing that the hybrid laminates damage state, in particular regarding the interfacial bonding of the layers, can be monitored not just through visual recordings of local strain and temperature development, but also through stress-displacement hysteresis analysis.