Fatigue of systemic lupus erythematosus in China: contributors and effects on the quality of life

Du, Xianjin; Zhao, Qian; Zhuang, Yuan; Chen, Haoyang; Shen, Biyu

doi:10.2147/ppa.s170984

Cited by 19 publications

(20 citation statements)

References 35 publications

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“…using the FSS found significant correlation between fatigue and disease duration, too. 35 In addition, we found correlation between this tool and some domains of HRQoL like physical and emotional health; Cleanthous et al. reported negative associations with both dimensions (physical and mental component scores) of HRQoL.…”

Section: Discussionsupporting

confidence: 52%

Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort

Elera-Fitzcarrald

Reátegui-Sokolova

Gamboa-Cárdenas

et al. 2020

Lupus

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Objective To define the factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE). Methods This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index –2 K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use were recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection followed a backward elimination procedure. Results Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4%) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-FT was 33.1 (10.8). On the multivariable analysis, age at diagnosis and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. Conclusions Age at diagnosis is negatively associated with fatigue whereas HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue.

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Section: Discussionsupporting

confidence: 52%

Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort

Elera-Fitzcarrald

Reátegui-Sokolova

Gamboa-Cárdenas

et al. 2020

Lupus

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“…A great body of evidence had reported that RA causes deterioration of all domains of QOL. Goma et al reported that all domains of SF36 were impaired in their 50 RA patients [43]. Moreover 464 RA patients were investigated by Katchamart and his colleagues for the quality of life using Thai version of EQ global health visual analogue scale (EQ VAS) and EuroQol five dimensional questionnaire (EQ5D).…”

Section: Resultsmentioning

confidence: 99%

Physical Ability and Quality of Life in Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Brief Comparison

Mahran

Fathi

Seddek

et al. 2020

Aktuelle Rheumatologie

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Background Patients with rheumatic disease are assumed to have low muscle performance, but few studies have been performed to prove this. Objective To investigate and compare muscle performance in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients and detect its correlation with disease activity, physical function level and quality of life. Patients and Methods Fifty RA patients, 50 SLE patients and 50 healthy controls were recruited for this observational, cross-sectional study. Muscle performance tests for the upper and lower limbs and the fatigue severity score were recorded. Assessments of the physical activity level using the frequency intensity time index and quality of life using the SF36 questionnaire were performed. The study was conducted over 4 months from January to April 2019. Results SLE patients showed better results of muscle performance than RA patients; however, both had lower results as compared to control. Disease activity was correlated to muscle performance tests in both diseases, except for the 30-second chair stand test in SLE (p=0.247). All domains of SF36 had a significant correlation with the performance tests in SLE (p≤0.05); however, only domains of physical function correlated with the tests in the RA group. Conclusion RA patients tend to have a lower muscle performance and physical activity level as compared to SLE patients and control.

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“…It is noteworthy that the arthritic effects can be observed in more than 95% of the affected individuals 6 . However, fatigue and tiredness are also frequent complaints when SLE is active 2,[7][8] .…”

Section: Introductionmentioning

confidence: 99%

“…People affected by SLE experience many changes in daily life, including, in addition to physical and psychological symptoms, decreased muscle strength, changes in rhythm and productivity at work, limitations related to treatment and changes in body self-image and self-esteem 4,7,9 . In this sense, for many patients, the disease challenges the future and the meaning of life 10 .…”

Section: Introductionmentioning

confidence: 99%

Duality of Living With Systemic Lupus Erythematosus: Fluctuating Between “Good Days” and “Bad Days”

Souza

Barreto²,

Teston

et al. 2021

Texto contexto - enferm.

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Objective: to learn the perception of individuals with Systemic Lupus Erythematosus about living with the disease. Method: an exploratory and descriptive research study, of a qualitative nature, carried out with 26 individuals undergoing treatment at the rheumatology outpatient clinic of a university hospital in southern Brazil. The data were collected in the period from February to July 2019, by means of semi-structured interviews that were audio-recorded and subjected to the thematic modality of content analysis. Results: a category entitled: “Fluctuating between good and bad days in living with Systemic Lupus Erythematosus”, composed of two subcategories that portray that living with Lupus is something unstable/fickle, emerged from the results. This is because, as a result of the periods of remission and exacerbation of the signs and symptoms of the disease, the patients experience a paradox of constant oscillation between ups and downs. Conclusion: it was learned that individuals with Lupus perceive that living with the disease is marked by an oscillation between good days and bad days, which are related to periods of remission and exacerbation of the manifestations of the disease, respectively.

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Fatigue of systemic lupus erythematosus in China: contributors and effects on the quality of life

Cited by 19 publications

References 35 publications

Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort

Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort

Physical Ability and Quality of Life in Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Brief Comparison

Duality of Living With Systemic Lupus Erythematosus: Fluctuating Between “Good Days” and “Bad Days”

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