A calculation model is developed that makes it possible to predict the fatigue limit s -1 of specimens with technological surface defects based on the data on the material microstructure and stress concentrator geometry. The fatigue test results are presented for specimens with technological defects under symmetric lateral bending that are made of Ti-6Al-4V titanium alloy condensate produced by the electron-beam physical vapor deposition method. The results obtained are used to calculate s -1 based on the developed model and are in very good agreement with the experimental data.