Fatores associados às interações medicamentosas em idosos internados em hospital de alta complexidade

Veloso, Ronara Camila de Souza Groia; Figueredo, Tácita Pires de; Barroso, Soraya Coelho Costa; Reis, Adriano Max Moreira

doi:10.1590/1413-81232018241.32602016

Cited by 19 publications

(21 citation statements)

References 25 publications

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“…The group with a high risk of DDIs was defined as advanced age, a diagnosed cardiovascular system disorder, complex medication regimen and so on (Yoon et al, 2018;Gallo et al, 2019;Veloso et al, 2019). Given that polypharmacy was commonly observed for the treatment of concurrent chronic conditions, it can be expected that the prevalence of DDIs among older adults will inherently increase (Prince et al, 2015;Yoon et al, 2018;Lea et al, 2019;Ruangritchankul et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

Zhao

Liu²,

Feng³

et al. 2022

Front. Pharmacol.

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Introduction: Polypharmacy are commonly observed among older adults with cardiovascular disease. However, multiple medications lead to increased risk of drug-drug interactions (DDIs). Therefore, identification and prevention actions related to harmful DDIs are expected in older adults. The study aimed to describe the prevalence of potential DDIs (pDDIs) in discharge prescriptions among older adults with chronic coronary syndrome (CCS).Methods: A single-center cross-sectional study was performed in a tertiary public hospital in Beijing, China. CCS patients aged 65 years and above who were admitted to cardiology wards over a 3-month period and alive at discharge were included. Electronic medical records and discharge prescriptions were reviewed. pDDIs were evaluated through the Lexi-Interact online.Results: pDDIs were identified in 72.9% of the 402 individuals (n = 293). A total of 864 pDDIs were obtained. 72.1% of patients were found with C DDIs (n = 290) and 20.3% were categorized in D and X DDIs (n = 82). The only X DDI was between cyclosporine and atorvastatin. Under category D, glycemia alterations within antidiabetics and increased chances of bleeding with antithrombotic were the most common. Concomitant use of clopidogrel and calcium channel blockers was a frequent situation within category C, followed by synergic blood pressure lowering agents and increased rosuvastatin concentration induced by clopidogrel.Conclusion: DDIs exposure was common in older CCS. DDIs screening tools should be introduced to alert potential adverse effects. Prescribers need to rigorously review or modulate therapies to prevent DDI-related adverse outcomes. Clinical pharmacists should be more involved in complex drug regimen management.

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Section: Introductionmentioning

confidence: 99%

Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

Zhao

Liu²,

Feng³

et al. 2022

Front. Pharmacol.

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“…Existem diferentes tipos de interação medicamentosa como por exemplo a interação Medicamento-Medicamento em que ocorre a interação entre dois medicamentos que podem diminuir ou aumentar as reações adversas. Além desses também existe a interação Medicamento-Alimento que pode interferir diretamente na absorção desses (VELOSO et al, 2019).…”

Section: Desenvovimentounclassified

XVI Jornada Acadêmica, 1º Encontro Anual de Iniciação Cientifica da UNINGÁ

Pelloso¹,

Romani²

2021

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“…Entretanto, não se descarta a possibilidade de que essas oscilações também podem ter relação direta com as políticas de segurança empregadas em cada hospital, no tocante ao uso de medicamentos, bem como com peculiaridades do processo de trabalho dos profissionais de saúde, principalmente no que se refere a carência de atuação de um farmacêutico clínico para realizar o acompanhamento farmacoterapêutica no setor , . 31,32 Com relação a polifarmácia, estudos anteriores corroboram com esse achado, nos quais houve relatos de prevalências que variaram entre 97,1% e 100%. 33,34 Não obstante a prática da polifarmácia seja bastante utilizada como medida clínica, objetivando uma melhor resposta e adesão ao tratamento, ela indica uma ameaça para a saúde do idoso, o que pode contribuir com os altos índices de mortalidade.…”

Section: Introdução (22%) Conclusionunclassified

Associated factors with the prescription of potentially inappropriate medication for older adult in a public hospital

Souza¹,

Santos²,

Cerqueira³

et al. 2021

Rev Bras Farm Hosp Serv Saude

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Objective: To evaluate the factors associated with the prescription of potentially inappropriate medications for the older adult (PIM) in a public hospital. Methods: A prospective cross-sectional study was carried out, whose data were collected from the medical records of older adult patients, admitted to the medical clinic of a public hospital, by a trained researcher, not a member of the staff. The collection took place between November 2018 and January 2019. The medical records of patients aged over 60 years, who were using at least one allopathic in-hospital medication, with a minimum of 48 hours of hospitalization, were included. Illegible prescriptions, or those containing only herbal medicines and / or vitamin supplements, were excluded. The PIMs were classified according to the Beers Criteria, 2019 update. Descriptive analysis of the data was performed using frequencies, means and standard deviation and bivariate analysis using the Chi-square and Fisher’s Exact tests, with a level of significance. p <0.05, using the software and SPSS® v.21.0. Results: 42 medical records of the older adult were analyzed, where a 100% prevalence of use of PIM and polypharmacy was identified. The number of PIMs per patient was significantly associated with females (p = 0.020), with a higher prevalence of older adult women who used between 1 and 4 PIMs (64.1%); diagnosis (p = 0.006), with a higher prevalence of older adult people with circulatory tract diseases (54.5% using 1-4 PIM), endocrine, nutritional and metabolic diseases (85.7% using 1-4 PIM) ) and diseases of the circulatory system (83.5% in use ≥5 PIM); polypharmacy (p = 0.002) with higher prevalence of older adult people who used ≥10 medications (52%, in use ≥ 5 PIM). The main therapeutic classes of PIM were of the alimentary tract and metabolism (46%) and nervous system (22%). Conclusion: It is concluded that the prescription of PIM was very high, where all the older adult in this study were exposed, being significantly associated with the female gender, polypharmacy, and diagnoses related to chronic comorbidities. It is necessary to raise the awareness of the team to adopt safer strategies and practices in the use of these drugs in order to minimize the exposure of the older adult to possible risks.

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Fatores associados às interações medicamentosas em idosos internados em hospital de alta complexidade

Cited by 19 publications

References 25 publications

Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

Potential drug-drug interactions in drug therapy for older adults with chronic coronary syndrome at hospital discharge: A real-world study

XVI Jornada Acadêmica, 1º Encontro Anual de Iniciação Cientifica da UNINGÁ

Associated factors with the prescription of potentially inappropriate medication for older adult in a public hospital

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