Fattiviracins, Antiviral Antibiotics Produced by an Actinomycete

Uyeda, Masaru

doi:10.3209/saj.17_57

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…These nucleosides may have potent biological or physiological effects. A series of nucleoside analogues were synthesized and exhibited potential antiviral activities against duck hepatitis B virus (DHBV) [ 19 ], herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV) [ 20 – 22 ]. All of those synthesized 2′-deoxyuridine analogues have special substituents on position C-5 of uridine moiety.…”

Section: Discussionmentioning

confidence: 99%

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus

et al. 2011

Marine Drugs

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One new nucleoside derivative, named 3-acetyl-5-methyl-2′-deoxyuridine (1), along with two known compounds 3,5-dimethyl-2′-deoxyuridine (2) and 3-methyl-2′-deoxyuridine (3), were isolated from the cultures of Streptomyces microflavus. This strain was an associated actinomycete isolated from the marine sponge Hymeniacidon perlevis collected from the coast of Dalian (China). Their structures were elucidated by detailed NMR and MS spectroscopic analysis as well as comparison with literature data.

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Section: Discussionmentioning

confidence: 99%

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus

et al. 2011

Marine Drugs

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“…Actinomycetes are Gram positive bacteria, filamentous structure which are form through asexual spores and branching filaments. Actinomycetes produce about 70% of available secondary metabolites from more than 22,000 known secondary metabolites [9]. These bacteria are widely distributed in soil and aquatic environment, consists 50% uncultivable soil microorganisms that is why it become most dominant and important group of soil microbes.…”

Section: Role Of Actinomycetes Bio-active Secondary Metabolitesmentioning

confidence: 99%

Fermentation Optimization for Actinomycetes as a Single Cell Protein: A Comprehensive Review

Ullah¹,

Ullah²,

Khan³

2020

Preprint

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Single cell proteins are the dead dried cells of microorganisms or purified protein isolated from microorganism’s cell culture, used as a food supplement to humans’ food and animals feed. World suffer from malnutrition particularly developing countries, due to rapid increase in population, increased the demand for protein and nutrients requirement. Bacteria is potential microorganism for SCP production due to high protein content, fast generation time, bio-active secondary metabolites production and can grow on various substrates. Actinobacteria species and strain have capability to produce biological active compounds, produced about two-thirds of antibiotics available in the market, actively used as antibiotics, antiprotozoal, antifungal, antiviral, anticancer, anticholesterol, antihelminth and immunosuppressant. Actinomycetes can be used as probiotic as well as single cell protein that will deal with antibiotic as well as protein source.

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“…Fattiviracins have macrocyclic diesters consisting of four D-glucose units and two (C24 and C33) hydroxy fatty acids. Fattiviracins have a potent activity against enveloped DNA viruses such as the herpes family, HSV-1 and VZV and enveloped RNA viruses such as influenza A and B viruses, and three strains of HIV-1, in the order of a few µg/ml of EC50.The producing organism of Fattiviracins is Streptomyces microflavus (Uyeda, 2003). Fattiviracins act on HIV-1 particles directly without lysis of the particles, and it affords the inhibition of viral entry into the host cells (Habib et al, 2001).…”

Section: Fattiviracinsmentioning

confidence: 99%

Diversity and Versatility of Actinomycetes and its Role in Antibiotic Production

Chaudhary¹,

Soni²,

Shrivastava³

et al. 2013

J App Pharm Sc

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This review summarizes about the actinomycetes and their capability to produce bioactive secondary metabolites, many of which have been successfully isolated and turned into useful drugs and other organic chemicals. Microbial pathogens are becoming increasingly resistant to available treatments so new antibiotics are needed, but the channel of compounds under development is scarce. There is frantic need of new microbial agents to fight against the antibiotic resistant strains of pathogenic microorganisms, which are rapidly increasing gradually. Therefore, actinomycetes hold a prominent position due to their diversity and proven ability to produce new bioactive compounds predominantly used in antibiotic production. A critical element in a drug discovery based on microbial extracts is the isolation of unexploited groups of microorganisms that are at the same time good producers of secondary metabolites. Few of the antibiotics produced by actinomycetes are included in this review along with their activities to prove the versatility of this powerful microbial organism. Many ecological niches still remain unexplored yet which needs to be studied for a greater diversity of novel actinomycetes. Different strains of actinomycetes generally produce different compounds. For this reason intensive efforts can be increased for isolation and screening of new strains to discover new compounds.

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Fattiviracins, Antiviral Antibiotics Produced by an Actinomycete

Cited by 8 publications

References 37 publications

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus

Fermentation Optimization for Actinomycetes as a Single Cell Protein: A Comprehensive Review

Diversity and Versatility of Actinomycetes and its Role in Antibiotic Production

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