Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women

Abstract

In overweight and obese women, FABP4 showed an independent association with parameters of left ventricular remodelling.

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

“…The previous publications are not directly comparable to our investigation because of their smaller sample sizes11 (N<200), referral bias,25, 26, 27 and focus on obese individuals,25, 26, 27 whereas our study sample comprised relatively healthy individuals. In this context, it is noteworthy that experimental studies have also yielded variable results.…”

“…Accordingly, investigators have related circulating concentrations of adipokines to imaging indices of cardiac remodeling. These prior studies have typically been conducted in small samples, or samples with an overrepresentation of obese individuals or elderly people, and usually focused on a single adipokine 10, 11, 13, 21, 22, 23, 24, 25, 26…”

“…We observed an inverse association between circulating FABP4 levels and LVMI. Prior studies analyzing associations between FABP4 levels and LVMI have been inconsistent with reports of both no associations11 and of positive associations 25, 26, 27…”

“…Prior investigations relating adipokines to cardiac structure and function have focused on single adipokines10, 11, 15, 16, 17, 18, 19, 20, 21 and related them to traditional measures of cardiac remodeling (such as LV mass [LVM]). These studies often focused on obese individuals with comorbidities16, 22, 23, 24, 25, 26, 27, 28 or the elderly20, 21, 29 and were limited by modest sample sizes. To our knowledge, no prior investigation has related a panel of adipokines of contemporary interest to a range of cardiac remodeling indices in a younger sample relatively free of comorbidities.…”

Can the use of blood-based biomarkers in addition to anthropometric indices substantially improve the prediction of visceral fat volume as measured by magnetic resonance imaging?

“…In a two-stage approach, we first tested the utility of nine novel adipokines, which have been reported to be associated with visceral and/or total adiposity in the literature (adiponectin [17,18], leptin [19,20], cathepsin S [21], cystatin C [22,23], retinol-binding protein 4 (RBP4) [24,25], fatty acidbinding protein 4 (FABP4) [26], lipopolysaccharide-binding protein (LBP) [27,28], resistin [29,30], and insulin [31]) to predict MRI-derived visceral fat volume in a discovery sample. Second, we investigated whether the additional use of 15 biomarkers from a routine clinical chemistry profile may facilitate the prediction of visceral fat volume, as routinely measured markers such as triglycerides [32], high-density lipoprotein (HDL) [32], uric acid [32], hemoglobin A1c (HbA1c) [32], gamma-glutamyl transferase (GGT) [33], alanine transaminase (ALT) [33], C-reactive protein (CRP) [33], or leukocytes [34] have also been shown to correlate with visceral obesity.…”