Fatty Acid Components of Rat Liver Lipids: Effect of Composition of the Diet and of Restricted Access to Food

Okey, Ruth; Shannon, Angela; Tinoco, J.; Ostwald, Rosemarie; Miljanich, P.

doi:10.1093/jn/75.1.51

Cited by 39 publications

(17 citation statements)

References 10 publications

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“…Similar, but less pronounced, sex differences in liver pl~ospholipid stearic acid/pal~nitic acid ratios have been reported for rats fed diets containi~~g cottonseed or coconut oil (12) and safflower oil (32). Since plasnla phospl~olipids are derived from the liver, estradiol inust exert its influence through that organ.…”

Section: Discussionsupporting

confidence: 52%

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Effect of Estradiol and Testosterone on the Fatty Acids of Plasma Cholesteryl Esters and Phospholipids in the Castrated Rat

Lyman¹,

Shannon²,

Ostwald³

et al. 1964

Can. J. Biochem.

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The effects of physiological doses of estradiol and testosterone on plasma cholesteryl ester and phospholipid fatty acid composition were investigated in castrated male rats. The animals were killed after 3 weeks on experiment, and their plasma cholesteryl esters and phospholipids were analyzed and coinpared with those of intact female and male rats.Estradiol appeared to be responsible for the increased proportion of plasma cholesteryl arachidonate seen in the female or estrogen-injected rats since the proportion of cholesteryl arachidonate in castrated control rats was lower and similar to that of male or testosterone-treated rats. Plasma phospholipids of female and estradiol-injected rats had a higher percentage of stearic acid relatii-e to palmitic acid. On the other hand, male, castrated control and testosteronetreated rats had higher proportions of palmitic acid. Fractio~latio~l of the plaslna phospholipids into cephalins, lecithins, sphingomyelins, and lysolecithins, and analyses of their fatty acids, revealed that a principal effect of estradiol was to increase proportions and amounts of stearic and arachidonic acids in the lecithin fraction.The results suggest that estradiol may influence the synthesis of a lecithin rich in stearic and arachidonic acid. A possible relationship between the arachidonic-acid-rich lecithin and the higher percentage of cholesteryl arachidonate in estradiol-treated rats is discussed.

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Section: Discussionsupporting

confidence: 52%

“…In males the proportion of palmitic acid was equal to or greater than that of stearic acid (1 I ) . Liver phospholipids showed similar fatty acid relationships, but the differences were not so large (12).…”

Section: Introductionmentioning

confidence: 90%

Effect of Estradiol and Testosterone on the Fatty Acids of Plasma Cholesteryl Esters and Phospholipids in the Castrated Rat

Lyman¹,

Shannon²,

Ostwald³

et al. 1964

Can. J. Biochem.

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“…Okey et al (1961) reported that in their experiments with rats, the fatty acid components of the liver lipids showed a greater capacity for variation with diet than those of the plasma.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous workers have reported results of fatty acid analyses for tissues of monogastric experimental animals (James et al 1957;Dole et al 1959;Lawrie et al 1961;Okey et al 1961;Swellet al 1961a;Getz et al 1962;Grande 1962) but, by comparison, the literature relating to ruminants is very small. Most of the results available for ovine tissues are from the period before gas chromatography analytical techniques were introduced, although Hartman and Shorland (1961) have published values obtained by this technique for the subcutaneous fats of ox and sheep, and Annison (1954) used this method in a study of the volatile fatty acids present in sheep blood.…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Components of Ovine Tissue Lipids, and The Response to Prolonged Protein Depletion

Horgan¹,

Masters²

1963

Aust. Jnl. Of Bio. Sci.

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SummaryThe lipids of ovina liver and plasma have been separated by silicic acid chromatography into cholesterol ester, triglyceride, free fatty acid, and phospholipid fractions. Fatty acid constituents of these fractions have been determined by gas chromatography. The lipid content of these tissues was also determined for animals subjected to a prolonged protein depletion. Several significant differences were caused by the experimental diet, with the liver showing more alterations than plasma. The unsaturated C 18 fatty acids were affected to the greatest degree.Implications of these results have been discussed in relation to comparative biochemistry and intermediary lipid metabolism.

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“…Thus there are histological differences in the cytoplasm (Korenchevsky, 1941) and nucleus (Hoffman & Swartz, 1963) and the liver of the male is more susceptible to spontaneous or induced carcinogenesis than that of the female (Rumsfeld, Miller & Baumann, 1951; Morris & Firminger, 1956;Berman, 1958;Reuber & Lee, 1968;Toth, 1968;Vesselinovitch, 1969). Bio¬ chemical differences between the sexes in nucleic acid content (Li, Peng & Nan, 1965), enzyme activity (Knox, Auerbach & Lin, 1956;Kato & Gillette, 1965;Kato, Takanaka & Takayanagi, 1968;Davies, Gigon & Gillette, 1968;De Baun, Rowley, Miller & Miller, 1968; Lewis, 1968), protein component (Bond, 1960(Bond, , 1962; Barzilai & Pincus, 1965; Rumke, Breekveldt-Kielich & van den Broecke-Siddre, 1970), and phospholipid metabolism and fatty-acid composition (Okey, Shannon, Tinoco, Ostwald & Miljanich, 1961 ;Holtzman & Gillette, 1968 Holtzman, Gram & Gillette, 1970) have been demonstrated. The present study is concerned with the effect of neonatal administration of testosterone and oestradiol on the metabolism of phospholipid in the liver microsomes of male and female rats.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Neonatal Administration of Sex Hormones on the Turnover of Hepatic Microsomal Phospholipid in Male and Female Rats

Yc¹

1971

Journal of Endocrinology

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The effect of neonatal administration of testosterone propionate and oestradiol benzoate on the metabolism of microsomal phospholipid in the liver of male and female rats was studied. Males had a greater uptake of radioactive phosphorus than females. Gonadectomy at the age of 4 weeks reduced the incorporation of 32P into the microsomal phospholipid. Administration of testosterone significantly increased 32P uptake both in the intact and ovariectomized females as well as in the castrated males, whereas oestradiol produced no effect. A sex difference of total microsomal phospholipid phosphorus was also found in the gonadectomized rats. Oestrogen caused no change in the intact animals but restored the level of phospholipid in ovariectomized female rats. On the other hand, testosterone significantly increased the total content of the phospholipid in the liver microsomes of both intact and gonadectomized male and female rats.

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Fatty Acid Components of Rat Liver Lipids: Effect of Composition of the Diet and of Restricted Access to Food

Cited by 39 publications

References 10 publications

Effect of Estradiol and Testosterone on the Fatty Acids of Plasma Cholesteryl Esters and Phospholipids in the Castrated Rat

Effect of Estradiol and Testosterone on the Fatty Acids of Plasma Cholesteryl Esters and Phospholipids in the Castrated Rat

Fatty Acid Components of Ovine Tissue Lipids, and The Response to Prolonged Protein Depletion

The Effect of Neonatal Administration of Sex Hormones on the Turnover of Hepatic Microsomal Phospholipid in Male and Female Rats

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