Fatty Acid Composition in Serum Lipids and Adipose Tissue in Patients with Morbus Crohn after Heal Resection

Johansson, C.; Walldius, Göran; Rössner, S

doi:10.1159/000199496

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…Studies of atopic dermatitis, to test the assumption of an abnormal fatty acid desaturation associated with this condition have also been negative (66). In patients with Crohn's disease, resection length was associated with the composition of fatty acids in the adipose tissue, and increased proportions of unsaturated fatty acids were found; but the authors attribute this to an increased demand for precursors or local prostaglandin synthesis, rather than to disease activity (67). In cystic fibrosis, on the other hand, where there is a malabsorption of fat, an expected reduction in polyunsaturated and monounsaturated fatty acids is seen, as compared to normal volunteers (68).…”

Section: Raementioning

confidence: 98%

Adipose Tissue as a Medium for Epidemiologic Exposure Assessment

Kohlmeier¹,

Kohlmeier²

1995

Environmental Health Perspectives

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In the United States, adipose tissue is rarely used as a medium for assessment of prior exposures in epidemiologic studies. Adipose tissue aspirations are in general less invasive and carry less risk than phlebotomy. Tissue samples can be analyzed for a wide number of epidemiologically important exposures. Beyond reflecting long-term energy balance, this tissue offers a relatively stable depot of triglyceride and fat-soluble substances, such as fat-soluble vitamins, and pesticides. As a tissue it represents the greatest reservoir of carotenoids in the body. Halogenated hydrocarbons may be measured in concentrations of hundreds-fold greater than those in blood of the same individuals. The composition of adipose tissue also reflects the long-term dietary intakes of a number of essential fatty acids. The turnover times of all of these substances in adipose tissue remain under-researched. Sampling and storage of adipose tissue, homogeneity of sampling sites, turnover times, and the effects of diet, age, gender, race, hormones, and disease on adipose tissue composition are discussed in this review of current knowledge about adipose tissue stability. Experience in the use of adipose tissue sampling in epidemiologic studies in various countries has shown that it is simple to conduct, requires little training, carries little risk, and does not result in excessive participant refusal. -Environ Health Perspect 103(Suppl 3): 99-106 (1995)

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Section: Raementioning

confidence: 98%

Adipose Tissue as a Medium for Epidemiologic Exposure Assessment

Kohlmeier¹,

Kohlmeier²

1995

Environmental Health Perspectives

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Influence of intestinal resection and type of diet on the digestive and metabolic utilization of fats in rats

Coves

Lisbona

Campos

et al. 1991

Nahrung

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The effects of the quality of dietary fat, and the influence of ursodeoxycholic acid, an exogenous bile acid, on the digestive and metabolic utilization of fat were studied in rats in which 50% of the distal small intestine was resected. The fat content of the diets was quantitatively equivalent (4%), and differed only in the type of fat: olive oil (diet A) or 1/3 medium chain triglycerides (MCT), 1/3 sunflower oil and 1/3 olive oil (diet B). The removal of 50% of the distal small intestine led to a highly significant decline in the digestive utilization of fat (ADC) in animals given diet A. Rats fed diet B showed an increase in ADC to values approaching those seen in control animals. The addition of ursodeoxycholic acid to diet B failed to cause a further rise in the ADC of fat. After intestinal resection, serum levels of triglycerides and cholesterol fell more markedly in animals given diet A than in the diet B group, while the addition of ursodeoxycholic acid to diet B led to no further change. Serum lipid levels showed no significant influence of intestinal resection, but did accurately reflect the differences in fat composition between the two types of diet tested.

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