Fatty Acid Composition of Epicardial and Subcutaneous Human Adipose Tissue

Pezeshkian, Masoud; Noori, Mohammad; Najjarpour-Jabbari, Hamideh; Abolfathi, Aliakbar; Darabi, Maryam; Darabi, Masoud; Shaaker, Maghsod; Shahmohammadi, Ghader

doi:10.1089/met.2008.0056

Cited by 84 publications

(62 citation statements)

References 28 publications

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“…Whether fatty-acid-binding protein 4 participates in the intracellular transport of FFAs from epicardial fat into the myocardium is plausible, but remains unexplored. Compared to subcutaneous adipose tissue, human epicardial fat appears to be rich in saturated fatty acids, including myristic acid (14:0), palmitic acid (16:0) and stearic acid (18:0), whereas unsaturated fatty acids, palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6) and linolenic acid (18:3n-3) are less abundant [19]. How FFAs are transported from the epicardial fat and reach the myocardium remains to be elucidated.…”

Section: Physiology Of Epicardial Adipose Tissuementioning

confidence: 99%

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features

Iacobellis

Bianco

2011

Trends in Endocrinology & Metabolism

466

407

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Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional contiguity to the myocardium and coronary arteries. Under physiological conditions, epicardial adipose tissue displays biochemical, mechanical and thermogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of proinflammatory cytokines. What influences this equilibrium remains unclear. Improved local vascularization, weight loss, and targeted pharmaceutical interventions could help to return epicardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological aspects of the epicardial fat and its numerous and innovative clinical applications. Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis.

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Section: Physiology Of Epicardial Adipose Tissuementioning

confidence: 99%

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features

Iacobellis

Bianco

2011

Trends in Endocrinology & Metabolism

466

407

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“…6 It is well known that energy production in the heart is highly dependent on FFA oxidation. Epicardial fat is rich in saturated fatty acids, and this enrichment and increased metabolism of FFAs in epicardial fat sustains myocardium energy supplies, especially during periods of high demand.…”

Section: Metabolic Functionsmentioning

confidence: 99%

Epicardial Fat in the Maintenance of Cardiovascular Health

Wu¹,

Zhang²,

Hamilton³

et al. 2017

Methodist DeBakey Cardiovascular Journal

108

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Epicardial fat is a unique adipose tissue located between the myocardium and the visceral layer of pericardium. This tissue is characterized by highly active fatty acid metabolism and highly expressed thermogenic genes. Epicardial fat and the underlying myocardium share the same microcirculation, suggesting a close and strong interaction between these two structures. Under physiological conditions, epicardial fat protects and supports the heart to exert its normal function. Many clinical studies have shown significant associations between increased amounts of epicardial fat and coronary artery disease (CAD). In patients with CAD, increased epicardial fat becomes inflammatory and may promote plaque development through secretion of proinflammatory cytokines and other mechanisms. Therefore, epicardial fat is a biomarker of cardiovascular risk and a potential therapeutic target for cardiovascular disease. Weight loss and pharmaceuticals can reduce epicardial fat and improve its protective physiological functions.

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“…This tissue also contains immune cells, ganglia, interconnecting nerves and a stromavascular fraction (115). EAT is rich in saturated fatty acids including myristic acid (14:0), palmitic acid (16:0) and stearic acid (18:0), whereas unsaturated fatty acids such as palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6) and linolenic acid (18:3n-3) are less abundant (116). The composition of EAT is essential because |50% to 70% of the energy to sustain the contractile function of the heart proceeds by the b-oxidation of long chain fatty acids (117,118).…”

Section: Epicardial Adipose Tissue In Atherosclerosis: From Inflammatmentioning

confidence: 99%

Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis

Luna-Luna

Moeini

Vargas‐Alarcón

et al. 2015

Archives of Medical Research

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Fatty Acid Composition of Epicardial and Subcutaneous Human Adipose Tissue

Abstract: Regional differences may be observed in fatty acid composition, suggesting a depot specific impact of stored fatty acids on adipocyte function and metabolism.

Cited by 84 publications

References 28 publications

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features

Epicardial Fat in the Maintenance of Cardiovascular Health

Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis

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