Fatty acid composition of liver triglycerides in various stages of fat deposition in the parenchyma

The fatty acid pattern of adipose tissue and liver triglycerides according to fat droplet size in liver parenchymal cells of diabetic subjects

“…The fatty acid composition of liver triglycerides found in this study confirms previous results [35]. It is similar to the findings of Laurell and Lundquist [26] in obese nondiabetics.…”

“…As stated earlier [35] and by other authors [3,33] oleic acid significantly increased with increasing fat deposition in liver. In our specimens a close correlation with fat droplet size could be found independently of the extent of fat deposition.…”

“…In previous gas-chromatographic studies from biopsy specimens we observed an increase of palmitic and oleic acid and a decrease of eicosapentaenoic acid (C 20:5) in liver triglyeerides of diabetics, together with a rise of the fat droplet size in the liver parenchymal cells [35]. The purpose of the present paper was to determine whether these results bear any relation to the fatty acid pattern of subcutaneous adipose tissue in diabetic subjects.…”

“…Cases with pathological histological findings such as hepatitis and cirrhosis were excluded. The liver fat depositions were classified into 4 categories according to the size of fat droplets independent of the amount of fat by means of an ocular net with a length of 110 or 250 ~m (35) In stage four there were 5 cases with normal body weight and fatty liver. The average age in stage one was 47.2, in stage two 38.9, in stage three 54.0 and in stage four 52.0 years.…”

In vivo characterization of the liver fat 1H MR spectrum

“…The types of triglyceride in the liver can be measured directly biochemically (13,14) or with high-field (500 MHz) NMR (4). However, these techniques require invasive tissue sample collection, which is impractical for large numbers of human subjects.…”