Ten healthy and twenty diabetic volunteers (type 1) received 15 capsules (à 450 mg) cod liver oil for 2 weeks daily in addition to a "normal" diet. The levels of eicosapentaenoic acid in the plasma phospholipids of both groups were increased after the treatment. The inhibition of the prostacyclin formation by LDL was diminished when the LDL was isolated after the treatment in comparison to LDL taken in the same concentration and from the same donors before it. The thromboxane B2 (TXB2) synthesis capacity of clotting whole blood, thrombin-induced TXB2 formation by platelets as well as the 15(S)-hydroxy-11 alpha,9 alpha-epoxymethano-5Z, 13E-prostadienoic acid-induced platelet aggregation were not altered by the treatment in healthy volunteers, whereas in diabetics the TXB2 formation capacity of clotting whole blood was decreased after the treatment in comparison with before it.

111 40 diabetic inpatients the fatty acid pattern of triglycerides in liver Iat and in subcutaneous adipose tissue was determined by gas liquid chromatography. With rising size oI fat droplets in liver parenehyreal cells there was a significant increase of palmitic acid (C:16), oleic acid (C 18: 1) and linoleie acid (C 18:2) as well as a decrease of myristoleic acid (C 14 : 1), araehidonic (C 20:4) and eieosapentaenoie acid (C 20:5) in liver tri-glyeerides, resulting in a fatty acid composition in big droplets similar to that of adipose tissue. Fatty acid pattern of subcutaneous depot fat was strikingly constant.

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