Fatty acid composition of the milk lipids of Fulani women and the serum phospholipids of their exclusively breast-fed infants

VanderJagt, Dorothy J.; Arndt, Christopher; Okolo, SN; Huang, Y. S.; Chuang, Lu-Te; Glew, Robert H.

doi:10.1016/s0378-3782(00)00111-0

Cited by 22 publications

(13 citation statements)

References 22 publications

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“…Our confidence in these relatively low arachidonic acid values rests on the fact that the fatty acid analyses in the present study were conducted by the same individual (L-TC) using the same analytical method employed in two other studies in which the arachidonic acid percentages were in the 11%–13% range [37,38]. The relatively low arachidonic status of healthy adults in New Mexico may be explained in part at least by the unusual dietary habits of the population.…”

Section: Discussionsupporting

confidence: 50%

Comparison of the fatty acid composition of the serum phospholipids of controls, prediabetics and adults with type 2 diabetes

Chuang

Glew

et al. 2012

JDM

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Objective Although abnormalities in the fatty acid composition of serum and red cell membrane phospholipids of patients with type 2 diabetes are well-documented, lacking are studies of this issue in prediabetic individuals. Materials/Methods For this cross-sectional study, we recruited 180 subjects (30–80 years), 56 of whom were normal with regard to glucose control (HbA1c, <5.7%), 61 who had prediabetes (HbA1c, 5.7%–6.4%) and 59 who had type 2 diabetes (HbA1c, >6.5%). Serum phospholipids were isolated and analyzed for fatty acids. Results Most importantly, the fatty acid compositions of the controls and prediabetic subjects were not different for 19 fatty acids. However, the fatty acid profile of the phospholipids of the patients with diabetes differed from the other two groups; the 14 to 18-carbon saturated fatty acids were decreased by 12%–26% whereas the unsaturated fatty acids 16:1n-7, 18:1n-9, 18:2n-6, 20:3n-6 and 20:4n-6 were increased by 45%–64%. Of note, the docosahexaenoic acid (DHA) status of individuals in all three study groups was remarkably low compared with international values, as indicated by DHA proportions in the 1.62%–2.07% range, and there were no differences between groups. The mean melting point of the phospholipid fatty acids of the diabetic patients (32.2°C) was significantly lower (p < 0.001) than that of the prediabetic subjects (38.1°C) and the controls (39.9°C) which were not different from each other. Conclusion These observations indicate that the fatty acid changes associated with type 2 diabetes follow the onset of the disease as opposed to being a causative factor of poor glucose control and insulin insensitivity.

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Section: Discussionsupporting

confidence: 50%

Comparison of the fatty acid composition of the serum phospholipids of controls, prediabetics and adults with type 2 diabetes

Chuang

Glew

et al. 2012

JDM

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“…Although the FA composition of serum PL in lactating women has been studied previously , to our knowledge this is the first report that separates and provides a detailed FA profile for distinct PL subclasses. PC was the major PL fraction (Fig.…”

Section: Resultsmentioning

confidence: 98%

“…Spear et al reported marked differences between milk and total serum lipid FA. Other authors have found that the proportions of linoleic, α‐linolenic, arachidonic (20:4 n‐6), and docosahexaenoic (22:6 n‐3, DHA) acids in serum PL are positively correlated with the percentages of these FA in milk lipids, which suggests that transfer of these critical FA from blood to milk is a relatively efficient process. However, those studies were limited to major FA and they did not report data about CE and TG serum lipid fractions.…”

Section: Introductionmentioning

confidence: 94%

Detailed fatty acid profile of serum lipid classes in lactating women and their relationship with milk fat

Gómez‐Cortés

Marín²,

Fuente

2016

Euro J Lipid Sci & Tech

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Little is known about fatty acid (FA) distribution among triacylglyceride (TG), cholesterol ester (CE), and phospholipid (PL) plasma lipid fractions in lactating women, and the relationships between these fractions and the FA profile of the milk that mothers produce. Milk fat and serum lipid FA compositions in lactating women were compared to investigate which serum lipids are the source of FA in milk fat. A TLC methodology was used to fractionate serum lipids including PL subclasses, that is, phosphatidylethanolamine (PE), phosphatidylcholine (PC), and sphingomyelin (SM). Plasma lipids consisted of CE (36.4%), TG (19.1%), PE (1.40%), PC (39.80%), and SM (3.29%). With regard to PL fractions, PE was characterized by the highest levels of 18:0, 20:4 n‐6, 22:6 n‐3, and alkenyl ethers. PC revealed 16:0 as the predominant FA, followed by 18:2 n‐6, 18:0, cis‐9 18:1, and 20:4 n‐6, whereas saturated FA from 16:0 to 24:0 were characteristic of SM. Although n‐6 and n‐3 polyunsaturated FA were mostly found in PE and PC, strong correlations were found for 18:2 n‐6 and 18:3 n‐3 between plasma TG and milk lipids. This study also shows that trans 18:1 isomers may be selectively incorporated into milk fat from specific serum fractions. Practical applications: An easy‐to‐use and inexpensive two‐stage TLC methodology to fractionate plasma lipids requiring only 1 mL of blood serum has been developed. Moreover, this study provides valuable information on the composition of serum lipids in lactating women, particularly with regard to PL classes, and their influence on the milk fat FA profile. Fatty acid transfer from serum lipids to milk fat in lactating women.

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“…On the other hand, the FA composition of breast milk shows considerable variation with regards to factors such as the duration of pregnancy, stage of lactation, maternal parity, and geographic region (7)(8)(9)(10)(11)(12)(13)(14)(15). Many studies have been performed to determine the content of FA in breast milk collected from mothers with preterm and term infants, but the information on the composition of milk from Turkish women has remained incomplete (16,17). In this study, we reported on the compositional changes of FA in breast milk during the first month of lactation and compared FA composition of breast milk donated by mothers giving birth with full-term and preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Comparing the fatty acid levels of preterm and term breast milk in Turkish women

Aydın¹,

TURAN²,

AYDIN³

et al. 2014

Turk J Med Sci

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The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.

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Fatty acid composition of the milk lipids of Fulani women and the serum phospholipids of their exclusively breast-fed infants

Cited by 22 publications

References 22 publications

Comparison of the fatty acid composition of the serum phospholipids of controls, prediabetics and adults with type 2 diabetes

Comparison of the fatty acid composition of the serum phospholipids of controls, prediabetics and adults with type 2 diabetes

Detailed fatty acid profile of serum lipid classes in lactating women and their relationship with milk fat

Comparing the fatty acid levels of preterm and term breast milk in Turkish women

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