Fatty acid deficiency signs predict the severity of reading and related difficulties in dyslexic children

Richardson, Alexandra J.; Calvin, Catherine; Clisby, C.; Schoenheimer, D.R.; Montgomery, Paul; Hall, Joshua; Hebb, Gillian S.; Westwood, Elizabeth; Talcott, Joel B.; Stein, John

doi:10.1054/plef.2000.0194

Cited by 76 publications

(49 citation statements)

References 17 publications

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“…In adults and children with dyslexia, signs of fatty acid deficiencies are correlated with the severity of dyslexic signs and symptoms [248,249]. Cerebral P-31 magnetic resonance in dyslexics indicate increased membrane PL turnover [250].…”

Section: Other Disordersmentioning

confidence: 99%

Omega-3 fatty acids and neuropsychiatric disorders

2005

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-Epidemiological evidence suggests that dietary consumption of the long chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), commonly found in fish or fish oil, may modify the risk for certain neuropsychiatric disorders. As evidence, decreased blood levels of omega-3 fatty acids have been associated with several neuropsychiatric conditions, including Attention Deficit (Hyperactivity) Disorder, Alzheimer's Disease, Schizophrenia and Depression. Supplementation studies, using individual or combination omega-3 fatty acids, suggest the possibility for decreased symptoms associated with some of these conditions. Thus far, however, the benefits of supplementation, in terms of decreasing disease risk and/or aiding in symptom management, are not clear and more research is needed. The reasons for blood fatty acid alterations in these disorders are not known, nor are the potential mechanisms by which omega-3 fatty acids may function in normal neuronal activity and neuropsychiatric disease prevention and/or treatment. It is clear, however, that DHA is the predominant n-3 fatty acid found in the brain and that EPA plays an important role as an anti-inflammatory precursor. Both DHA and EPA can be linked with many aspects of neural function, including neurotransmission, membrane fluidity, ion channel and enzyme regulation and gene expression. This review summarizes the knowledge in terms of dietary omega-3 fatty acid intake and metabolism, as well as evidence pointing to potential mechanisms of omega-3 fatty acids in normal brain functioning, development of neuropsychiatric disorders and efficacy of omega-3 fatty acid supplementation in terms of symptom management.

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Section: Other Disordersmentioning

confidence: 99%

Omega-3 fatty acids and neuropsychiatric disorders

2005

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“…50 Furthermore, using Bayley Scales of infant development, a 7.3% increase in the Mental Development Index was noted for offspring receiving an early dietary supply of DHA, 51 whereas a low intake of o3FAs predicted poorer reading, spelling, auditory memory and general ability in males. 52 Despite potential deficiency in early life, supplementation with o3FAs appears to subsequently confer positive health benefits in some children.…”

Section: Brain Functionmentioning

confidence: 99%

Time for an oil check: the role of essential omega-3 fatty acids in maternal and pediatric health

Genuis

Schwalfenberg

2006

J Perinatol

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“…Enfin, un mauvais statut en acides gras poly-insaturés, donc en ω-3, serait en relation avec le risque de rechute à l'addiction à la cocaïne [16]. Dans la dyslexie, des anomalies dans le profil sanguin en acides gras ont été observées chez les garçons, mais pas chez les filles [17]. Dans l'autisme, une diminution du taux d'acides gras polyinsaturés à très longues chaînes carbonées a été observée dans les hématies; en parallèle, une diminution des concentrations en acides gras ω-3 (réduction de 23% en DHA), sans modification des taux d'acides gras ω-6, a été notée dans le sérum [18].…”

Section: Nomenclature Des Acides Gras Poly-insaturésunclassified

Acides gras ω-3 et troubles psychiatriques

Bourre

2005

Med Sci (Paris)

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Fatty acid deficiency signs predict the severity of reading and related difficulties in dyslexic children

Cited by 76 publications

References 17 publications

Omega-3 fatty acids and neuropsychiatric disorders

Omega-3 fatty acids and neuropsychiatric disorders

Time for an oil check: the role of essential omega-3 fatty acids in maternal and pediatric health

Acides gras ω-3 et troubles psychiatriques

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