Fatty acid methyl esters as a potential therapy against cerebral ischemia

Lee, Reggie Hui‐Chao; Vasquez, Juan Jose Goyanes; Klein, Daniel D.; Valido, Stephen E.; Chen, Joseph A.; Lerner, F.; Neumann, Jake T.; Lin, Hung Wen

doi:10.1051/ocl/2015040

Cited by 6 publications

(1 citation statement)

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“…In addition, both fatty acid esters can provide neuroprotection in focal and global cerebral ischemia in rats [48]. These results were further confirmed by , who also stated that methyl esterification of fatty acids is related to neuroprotective abilities and vasodilation [49].…”

Section: Gc-ms Analysismentioning

confidence: 52%

β-Amyrin Rich Bombax ceiba Leaf Extract with Potential Neuroprotective Activity against Scopolamine-Induced Memory Impairment in Rats

Mostafa¹

2018

Rec.Nat.Prod.

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The neuroprotective potential of Bombax ceiba L. (Malvaceae) leaves extract (BCLE) was evaluated herein for the first time. Memory impairment was induced in rats by scopolamine (SC) administration for seven days (1.5 mg/kg/day, i.p.). BCLE (200 mg/kg) or donepezil (1mg/kg) was administered orally a week before and then concomitantly with SC for another week. BCLE improved the rats' behaviors estimated by Morris water maze and passive avoidance tests, where the rats showed prolongation in time spent in platform quadrant and step-through latency, respectively, compared to administration of SC alone. BCLE also ameliorated the antioxidant parameters (Catalase with malondialdehyde (MDA), and the SC-induced elevation of acetylcholinesterase (AChE) in rats' brain tissues. Histopathological studies supported the above results. BCLE phytochemical study resulted in isolation and structural elucidation of β-sitosterol linoleate (first to be isolated from the genus) and β-amyrin. Twenty-seven compounds (39.35%) were identified in BCLE by gas chromatography/mass spectrometry (GC/MS). The major components were triterpenoids (69.82%), composing mainly of β-amyrin (45.28%), lupeol (15.03%) and olean-12-en-3-one (6.27%), in addition to fatty acid esters (13.37%) and steroids (7.75%), which were rich in methyl palmitate (9.87%) and stigmasterol acetate (4.91%), respectively. These compounds may be responsible for ameliorating the SC-induced oxidative stress and cholinergic dysfunction.

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Section: Gc-ms Analysismentioning

confidence: 52%

β-Amyrin Rich Bombax ceiba Leaf Extract with Potential Neuroprotective Activity against Scopolamine-Induced Memory Impairment in Rats

Mostafa¹

2018

Rec.Nat.Prod.

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Neuroprotective Agents

Jain¹

2019

Springer Protocols Handbooks

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Comparative study of properties and fatty acid composition of some neat vegetable oils and waste cooking oils

Awogbemi

Onuh

Inambao

2019

International Journal of Low-Carbon Technologies

109

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Vegetable oils have been used as a feedstock for fatty acid methyl ester (FAME) production. The high cost of neat vegetable oil and its impact on food security have necessitated its replacement as a feedstock for FAME by used vegetable oil, also known as waste cooking oil (WCO). This study compares the properties and fatty acid (FA) compositions of samples of neat vegetable oil with those of samples of WCO, collected from restaurants and takeaway outlets at the point of disposal. The samples were subjected to property determination and pyrolysis gas chromatography mass spectrometer (PYGCMS) analysis. Analysis showed that degree of usage and the type of food items originally fried in the oil substantially affected its properties and FA composition. Density of neat vegetable oil varied between 904.3 and 919.7 kg/m3 and of WCO between 904.3 and 923.2 kg/m3. The pH of neat vegetable oil varied between 7.38 and 8.63 and of WCO between 5.13 and 6.61. The PYGCMS analysis showed that neat palm oil contains 87.7% unsaturated FA and 12.3% saturated FA, whereas neat sunfoil contains 74.37% saturated FA and 25% polyunsaturated FA. Generally, neat vegetable oils consisted mainly of saturated FAs and polyunsaturated FAs, whereas the WCO contained mainly of saturated FAs and monounsaturated FAs. This research confirms the suitability of WCO as feedstock for FAME.

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Fatty acid methyl esters as a potential therapy against cerebral ischemia

Cited by 6 publications

References 50 publications

β-Amyrin Rich Bombax ceiba Leaf Extract with Potential Neuroprotective Activity against Scopolamine-Induced Memory Impairment in Rats

β-Amyrin Rich Bombax ceiba Leaf Extract with Potential Neuroprotective Activity against Scopolamine-Induced Memory Impairment in Rats

Neuroprotective Agents

Comparative study of properties and fatty acid composition of some neat vegetable oils and waste cooking oils

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