2021
DOI: 10.1111/iwj.13547
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Fatty acid potassium improves human dermal fibroblast viability and cytotoxicity, accelerating human epidermal keratinocyte wound healing in vitro and in human chronic wounds

Abstract: Effective cleaning of a wound promotes wound healing and favours wound care as it can prevent and control biofilms. The presence of biofilm is associated with prolonged wound healing, increased wound propensity to infection, and delayed wound closure. Anionic potassium salts of fatty acids are tested with commonly used anionic surfactants, such as sodium laureth sulphate (SLES) and sodium lauryl sulphate/sodium dodecyl sulphate (SLS/SDS). The normal human dermal cells demonstrated significantly greater viabili… Show more

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“…48 h treatment of HaCat cells of LS I caused significant cytotoxicity in a range above 0.5%. This is in line with previous research in which a high concentration of soaps or other care products significantly reduces cell number after a short [ 36 , 37 ] and long exposition [ 38 ]. Both Cocamidopropyl Betaine (LS II) and CocamidopropylHydroxysultaine (LS III) did not affect the cytotoxic properties of LS I.…”
Section: Discussionsupporting
confidence: 92%
“…48 h treatment of HaCat cells of LS I caused significant cytotoxicity in a range above 0.5%. This is in line with previous research in which a high concentration of soaps or other care products significantly reduces cell number after a short [ 36 , 37 ] and long exposition [ 38 ]. Both Cocamidopropyl Betaine (LS II) and CocamidopropylHydroxysultaine (LS III) did not affect the cytotoxic properties of LS I.…”
Section: Discussionsupporting
confidence: 92%