Fatty-Acid Preference Changes during Development in Drosophila melanogaster

Fougeron, Anne-Sophie; Farine, Jean‐Pierre; Flaven‐Pouchon, Justin; Everaerts, Claude; Ferveur, Jean‐François

doi:10.1371/journal.pone.0026899

Cited by 36 publications

(29 citation statements)

References 60 publications

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“…preferences for them. Larva prefer unsaturated fatty acids (UFAs), while the adults prefer saturated fatty acids (SFAs) [49]. FA are also sensed by the GRNs on the labellum.…”

Section: The Molecular Basis For Water Co2 and Fatty Acid Taste In Dmentioning

confidence: 99%

Taste Sensation inDrosophila melanoganster

Lee

Poudel

2014

Hanyang Med Rev

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Animals find nutritious foods to survive, while avoiding aversive and toxic chemicals through the chemosensory faculties of olfaction and taste. The olfaction is comparatively well characterized, but the studies of taste are only recently developing since after 2000. Genetic, immunohistochemistry, and electrophysiological studies with knock-out transgenic mice opened up the taste field in mammals. Taste in insects has been only recently been studied after mammalian taste receptors were identified. Flies also discriminate the differences of sweet, salty and sour food, while being able to detect and reject potential foods contaminated with toxins or detrimental chemicals. These discriminatory abilities indicate that flies house basic taste receptors in their taste organs like humans. For the last decade, the sweet and bitter gustatory receptors in Drosophila have been characterized. In this review, we compare the taste anatomy between humans and insects. We also introduce five canonical taste sensations in Drosophila. In addition, we introduce new taste repertoires, that fruit flies can sense water and fatty acids as well as the carbonation buffer in beverage. These studies on simple model organisms will open up a new potential for scientists to further investigate these characteristics in vertebrates.

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“…preferences for them. Larva prefer unsaturated fatty acids (UFAs), while the adults prefer saturated fatty acids (SFAs) [49]. FA are also sensed by the GRNs on the labellum.…”

Section: The Molecular Basis For Water Co2 and Fatty Acid Taste In Dmentioning

confidence: 99%

Taste Sensation inDrosophila melanoganster

Lee

Poudel

2014

Hanyang Med Rev

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“…Physiologically, there appears to be no requirement for 20-carbon PUFAs in D. melanogaster , as flies raised in the absence of 20-carbon PUFAs are healthy and fertile (Shen et al, 2010; Hammad et al, 2011). Interestingly, D. melanogaster larvae have a preference for food enriched in unsaturated fatty acids whereas adults display a preference for saturated fatty acids (Fougeron et al, 2011). Although the reason underlying the stage-specific preferences for fatty acids is yet unknown, this differential preference may reflect the varying nutritional requirements during development (Shen et al, 2010; Hammad et al, 2011).…”

Section: Fatty Acid Signaling In Drosophilamentioning

confidence: 99%

Polyunsaturated fatty acid derived signaling in reproduction and development: Insights from Caenorhabditis elegans and Drosophila melanogaster

Vrablik

Watts

2013

Molecular Reproduction Devel

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SUMMARY Polyunsaturated fatty acids (PUFAs) exhibit a diverse range of critical functions in biological systems. PUFAs modulate the biophysical properties of membranes and, along with their derivatives, the eicosanoids and endocannabinoids, form a wide array potent lipid signaling molecules. Much of our early understanding of PUFAs and PUFA-derived signaling stems from work in mammals; however, technological advances have made comprehensive lipid analysis possible in small genetic models such as Caenorhabditis elegans and Drosophila melanogaster. These models have a number of advantages, such as simple anatomy and genome-wide genetic screening techniques, which can broaden our understanding of fatty-acid-derived signaling in biological systems. Here we review what is known about PUFAs, eicosanoids, and endocannabinoids in the development and reproduction of C. elegans and D. melanogaster. Fatty acid signaling appears to be fundamental for multicellular organisms, and simple invertebrates often employ functionally similar pathways. In particular, studies in C. elegans and Drosophila are providing insight into the roles of PUFAs and PUFA-derived signaling in early developmental processes, such as meiosis, fertilization, and early embryonic cleavage.

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“…It has been reported that insects can discriminate long-chain dietary fatty acids. Drosophila melanogaster ( D. melanogaster ) larvae prefer dietary unsaturated fatty acids while the adults generally prefer saturated fatty acids [9]. Low levels of diet fat can enhance the lifespan of the blowfly, while high-fat diets can cause more rapid death [10].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Transcriptome of Blowfly Chrysomya megacephala (Fabricius) Larvae in Responses to Different Edible Oils

Zhang

Yang

et al. 2013

PLoS ONE

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Background Chrysomya megacephala (Fabricius), a prevalent necrophagous blowfly that is easily mass reared, is noted for being a mechanical vector of pathogenic microorganisms, a pollinator of numerous crops, and a resource insect in forensic investigation in the postmortem interval. In the present study, in order to comprehensively understand the physiological and biochemical functions of C. megacephala, we performed RNA-sequencing and digital gene expression (DGE) profiling using Solexa/Illumina sequencing technology.Methodology/Principal FindingsA total of 39,098,662 clean reads were assembled into 27,588 unigenes with a mean length of 768 nt. All unigenes were searched against the Nt database, Nr database, Swiss-Prot, Cluster of Orthologous Groups (COG) and Kyoto Encyclopedia of Genes and Genome (KEGG) with the BLASTn or BLASTx algorithm (E-value<0.00001) for annotations. In total, 7,081 unigenes and 14,099 unigenes were functionally classified into 25 COG categories and 240 KEGG pathways, respectively. Furthermore, 20,216 unigenes were grouped into 48 sub-categories belonging to 3 main Gene Ontology (GO) categories (ontologies). Using the transcriptome data as references, we analyzed the differential gene expressions between a soybean oil-fed group (SOF) and a lard oil-fed group (LOF), compared to the negative control group (NC), using the DGE approach. We finally obtained 1,566 differentially expressed genes in SOF/NC, and 1,099 genes in LOF/NC. For further analysis, GO and KEGG functional enrichment were performed on all differentially expressed genes, and a group of differentially expressed candidate genes related to lipometabolism were identified.Conclusions/SignificanceThis study provides a global survey of C. megacephala and provides the basis for further research on the functional genomics of this insect.

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Fatty-Acid Preference Changes during Development in Drosophila melanogaster

Cited by 36 publications

References 60 publications

Taste Sensation inDrosophila melanoganster

Taste Sensation inDrosophila melanoganster

Polyunsaturated fatty acid derived signaling in reproduction and development: Insights from Caenorhabditis elegans and Drosophila melanogaster

Analysis of the Transcriptome of Blowfly Chrysomya megacephala (Fabricius) Larvae in Responses to Different Edible Oils

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