Fatty acid-rich volatile oil from Syagrus coronata seeds has larvicidal and oviposition-deterrent activities against Aedes aegypti

Santos, Leilane Marina Morais dos; Nascimento, Jéssica Silva; Santos, Mirela Araújo Gomes dos; Marriel, Nadja Biondine; Bezerra-Silva, Patrícia Cristina; Rocha, Suyana Karolyne Lino da; Silva, Alexandre G.; Correia, Maria T.S.; Paiva, Patrícia Maria Guedes; Martins, Gustavo Ferreira; Navarro, Daniela Maria do Amaral Ferraz; Silva, Márcia V.; Napoleão, Thiago Henrique

doi:10.1016/j.pmpp.2017.05.008

Cited by 22 publications

(8 citation statements)

References 37 publications

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“…In addition, it has a number of applications in folk medicine including snakebites, ocular inflammations, mycoses, wound healing, and spinal pain treatment [18]. Various biological activities have been reported for S. coronata seed oil, including antibacterial and insecticidal properties [16,19]. In addition, it has shown moisturizing property [20].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model

Santos

Filho

Nascimento

et al. 2019

Microbial Pathogenesis

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In this study, essential oil extracted from Syagrus coronata seeds (SCEO) was evaluated for antibacterial and antibiofilm activities against Staphylococcus aureus; in addition, Galleria mellonella model was used as an in vivo infection model. SCEO was mainly composed by fatty acids (89.79%) and sesquiterpenes (8.5%). The major components were octanoic acid, dodecanoic acid, decanoic acid and γ-eudesmol. SCEO showed bactericidal activity (minimal bactericidal concentration from 312 to 1250 µg/mL) against all tested S. aureus clinical isolates, which showed distinct biofilm-forming and multiple drug resistance phenotypes. SCEO weakly reduced biomass but remarkably decreased cell viability in pre-formed biofilms of S. aureus isolate UFPEDA-02 (ATCC-6538). Electron microscopy analysis showed that SCEO treatments decreased the number of bacterial cells (causing structural alterations) and lead to loss of the roughness in the multiple layers of the three-dimensional biofilm structure. In addition, overproduction of exopolymeric matrix was observed. SCEO at 31.2 mg/kg improved the survival of G. mellonela larvae inoculated with UFPEDA-02 isolate and reduced the bacterial load in hemolymph and melanization. In conclusion, SCEO is an antibacterial agent against S. aureus strains with different resistance phenotypes and able to disturb biofilm architecture. Our results show SCEO as a potential candidate to drug development.

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Section: Accepted Manuscriptmentioning

confidence: 99%

“…Previous studies have reported that S. coronata oils are dominated by free carboxylic acids, accounting for approximately 80% of the total composition, and octanoic acid has been reported as the major volatile component of S. coronata oil [15,16,19].…”

Section: Chemical Composition Of Sceomentioning

confidence: 99%

Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model

Santos

Filho

Nascimento

et al. 2019

Microbial Pathogenesis

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“…larvae has been investigated in recent studies [1,37]. Among the explanations of this mechanism are the ultrastructural alterations of organs such as anal papillae [38], intestinal and tracheal system damage [1], inhibition of enzymatic activity [39], and morphological aberrations [40]. In this study, we investigated the effect of ACERF and annonacin on the inhibition of proteins important for the development of Aedes spp.…”

Section: Resultsmentioning

confidence: 99%

Larvicidal and Enzymatic Inhibition Effects of Annona Muricata Seed Extract and Main Constituent Annonacin against Aedes Aegypti and Aedes Albopictus (Diptera: Culicidae)

et al. 2019

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The mosquitoes Aedes aegypti and Aedes albopictus are vectors of arboviruses that cause dengue, zika and chikungunya. Bioactive compounds from plants are environmentally sustainable alternatives to control these vectors and thus the arboviruses transmitted by them. The present study evaluated the larvicidal activity of an acetogenin-rich fraction (ACERF) and its main constituent annonacin obtained from Annona muricata seeds on Ae. aegypti and Ae. albopictus. The larvicidal assays were performed using different concentrations to calculate the LC50 and LC90 values observed 24 h after exposure to the treatment. Annonacin was more active against Ae. aegypti (LC50 2.65 μg·mL−1) in comparison with Ae. albopictus (LC50 8.34 μg·mL−1). In contrast, the acetogenin-rich fraction was more active against Ae. albopictus (LC50 3.41 μg·mL−1) than Ae. aegypti (LC50 12.41 μg·mL−1). ACERF and annonacin treated larvae of Ae. aegypti and Ae. albopictus showed significant differences in the inhibition of their metabolic enzymes when compared to untreated larvae. The results demonstrate the relevant larvicidal action of the acetogenin-rich fraction and annonacin showing the potential to develop new products for the control of Ae. aegypti and Ae. albopictus.

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“…In addition to the pharmacological properties already mentioned in this article, plants of the Syagrus genus still have other possible applications (Table 2) [13,14,[70][71][72][73][74][75][76][77][78][79][80], mainly due to their chemical composition. e areas that stand out the most are biotechnology, for biodiesel production at an equal quality or better than the biodiesels on the market.…”

Section: Other Applicationsmentioning

confidence: 99%

Biological Potential of Products Obtained from Palm Trees of the Genus Syagrus

Coriolano

Alves

Cavalcanti

2021

Evidence-Based Complementary and Alternative Medicine

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Medicinal plants have been used for centuries by communities worldwide, as they have diverse biological properties and are effective against numerous diseases. The genus Syagrus stands out for its versatility and for so many activities presented by these palm trees, mainly due to its rich chemical and fatty acid compositions. The genus has antibacterial potential, has antibiofilm, antiparasitic, antioxidant, prebiotic, antiulcerogenic, anticholinesterase, and hypoglycemic activities, and can produce biodiesel, amid others. Among all species, Syagrus coronata and Syagrus romanzoffiana stand out, presenting the greatest number of activities and applications. The secondary metabolites obtained from these palm trees present high activity even in low concentrations and can be used against infections and chronic diseases. Furthermore, these plants have been used in some communities for years and have presented healing properties, especially in inflammatory processes. Therefore, the Syagrus genus proves to be promising, which shows a lot of therapeutic potential.

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Fatty acid-rich volatile oil from Syagrus coronata seeds has larvicidal and oviposition-deterrent activities against Aedes aegypti

Cited by 22 publications

References 37 publications

Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model

Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model

Larvicidal and Enzymatic Inhibition Effects of Annona Muricata Seed Extract and Main Constituent Annonacin against Aedes Aegypti and Aedes Albopictus (Diptera: Culicidae)

Biological Potential of Products Obtained from Palm Trees of the Genus Syagrus

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