2012
DOI: 10.1074/jbc.m111.303529
|View full text |Cite
|
Sign up to set email alerts
|

Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase

Abstract: Background: Angiopoietin-like protein 4 regulates plasma triglyceride metabolism by modulating the activity of lipoprotein lipase. Results: Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and reduce its effect on lipoprotein lipase. Conclusion: Fatty acids play a role in modulating the effects of angiopoietin-like protein 4. Significance: A novel mechanism for regulation of the action of angiopoietin-like protein 4 is proposed.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
19
0

Year Published

2013
2013
2024
2024

Publication Types

Select...
9

Relationship

2
7

Authors

Journals

citations
Cited by 26 publications
(19 citation statements)
references
References 62 publications
0
19
0
Order By: Relevance
“…Inhibition could be reversed and active LPL released when appropriate nutritional cues emerged. We can only speculate on the nature of these cues, but certain biological molecules such as free fatty acids reduce ANGPTL4 inhibition of LPL (46). Because fatty acids are mobilized to the circulation from adipose tissue upon fasting (47), they are unlikely to be the specific cue that releases ANGPTL4 inhibition of LPL.…”
Section: Discussionmentioning
confidence: 99%
“…Inhibition could be reversed and active LPL released when appropriate nutritional cues emerged. We can only speculate on the nature of these cues, but certain biological molecules such as free fatty acids reduce ANGPTL4 inhibition of LPL (46). Because fatty acids are mobilized to the circulation from adipose tissue upon fasting (47), they are unlikely to be the specific cue that releases ANGPTL4 inhibition of LPL.…”
Section: Discussionmentioning
confidence: 99%
“…The WD-mediated induction of Angptl4 may play a direct role in the plasma lipid changes seen in our LDLR Ϫ / Ϫ mice. Angptl4 is a protein that interacts with LPL, decreasing its activity ( 33,34 ). Globally knocking out Angptl4 in apoE Ϫ / Ϫ mice dramatically reduced plasma triglyceride levels, signifi cantly reduced plasma cholesterol levels, and reduced lesion size by 75% ( 35 ).…”
Section: Discussionmentioning
confidence: 99%
“…Remaining LPL activity at the indicated time points was measured using DGGR as a substrate as described previously (27). The curves for inactivation of LPL were analyzed by simple monoexponential decay kinetics.…”
Section: Methodsmentioning
confidence: 99%