Fatty Acids from Lipids of Marine Organisms: Molecular Biodiversity, Roles as Biomarkers, Biologically Active Compounds, and Economical Aspects

Bergé, Jean‐Pascal; Barnathan, Gilles

doi:10.1007/b135782

Cited by 252 publications

(251 citation statements)

References 380 publications

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“…In order to gain further insight into the possible correlations between the taxonomy, metabonomics, and ecological properties of the source organisms and the NF-B inhibitory potential of the extracts, we evaluated the FA composition of the microalgal samples included in the screening. Algae are known to be rich in FAs [70][71][72], and their FA composition can, to a certain extent, be used as fingerprints for their taxonomy or for the environmental conditions of their habitat [32,34,70]. Little difference could be seen between the FA composition of the two genera.…”

Section: Discussionmentioning

confidence: 99%

“…Since marine microorganisms have become widely recognized as a particularly promising source of novel bioactive natural products [25][26][27][28], we also screened 43 extracts from microalgae and cyanobacteria provided by the Culture Collection of Algae and Protozoa (CCAP) (Dunstaffnage Marine Laboratory, Oban, U.K.) and from bacteria isolated from Scottish and Costa Rican marine sediments and cultured in our laboratories. Notably, marine microorganisms are rich sources of polyunsaturated fatty acids (PUFA) and of carotenoids, which are likely to interfere with the activation of NF-B through their strong anti-oxidant activity [29][30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

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The inhibition of TNF-α-induced NF-κB activation by marine natural products

Folmer

Jaspars

Solano

et al. 2009

Biochemical Pharmacology

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, et al.. The inhibition of TNF-α induced NF-κB activation by marine natural products. Biochemical Pharmacology, Elsevier, 2009, 78 (6) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 AbstractThe deregulated activation of NF-B is associated with cancer development and inflammatory diseases. With the aim to find new NF-B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins.Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF--induced NF-B-DNA binding as well as TNF- induced IB degradation and nuclear translocation of p50/p65. Furthermore, we observed inhibition of NF-B activation induced by an overexpression of TNFR1, TRAF2, TRADD, or IKK Interestingly, natural products inhibited IKK kinase as well as the 26S proteasome proteolytic activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Folmer

Jaspars

Solano

et al. 2009

Biochemical Pharmacology

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“…Using fatty acids, bacteria, phytoplankton classes, and zooplankton orders may be distinguished in marine samples [81,88,93]. Table 1 gives a listing of recently used fatty acids and it can be seen that many compounds are not unique biomarkers.…”

Section: Molecular Biomarkersmentioning

confidence: 99%

Lipids in Marine Ecosystems

2013

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Lipids provide the densest form of energy in marine ecosystems. They are also a solvent and absorption carrier for organic contaminants and thus can be drivers of pollutant bioaccumulation. Among the lipids, certain essential fatty acids and sterols are considered to be important determinants of ecosystem health and stability. Fatty acids and sterols are also susceptible to oxidative damage leading to cytotoxicity and a decrease in membrane fluidity. The physical characteristics of biological membranes can be defended from the influence of changing temperature, pressure, or lipid peroxidation by altering the fatty acid and sterol composition of the lipid bilayer. Marine lipids are also a valuable tool to measure inputs, cycling, and loss of materials. Their heterogeneous nature makes them versatile biomarkers that are widely used in marine trophic studies, often with the help of multivariate statistics, to delineate carbon cycling and transfer of materials. Principal components analysis has a strong following as it permits data reduction and an objective interpretation of results, but several more sophisticated multivariate analyses which are more quantitative are emerging too. Integrating stable isotope and lipid data can facilitate the interpretation of both data sets and can provide a quantitative estimate of transfer across trophic levels.

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“…In bacteria, EPA and DHA are synthesized de novo by polyunsaturated fatty acid synthase pfa genes following the polyketide biosynthesis pathway (Metz et al 2001;Orikasa et al 2004;2006b), rather than by chain elongation and oxygen-dependent desaturation of existing fatty acids. The bacterial polyketide biosynthesis pathway has some benefits for the production of n-3 LC-PUFAs compared with the fatty acid elongation and desaturation processes, which are summarized in some reviews (Ratledge 2004;Bergé and Barnathan 2005;Okuyama et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA

Orikasa

Ito²,

Nishida

et al. 2007

Biotechnol Lett

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Cellular eicosapentaenoic acid (EPA) makes up approximately 3% of total fatty acids in Escherichia coli DH5α, a strain that carries EPA biosynthesis genes (pEPAΔ1). EPA was increased to 12% of total fatty acids when the host cell coexpressed the vector pGBM3::sa1(vktA), which carried the high-performance catalase gene, vktA. Where this vector was coexpressed, the transformant accumulated a large amount of VktA protein. However, the EPA production of cells carrying the vector that included the insert lacking almost the entire vktA gene was approximately 6%. This suggests that the retention of a large DNA insert in the vector and the accumulation of the resulting protein, but not the catalytic activity of VktA catalase, would potentially be able to increase the content of EPA.

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Fatty Acids from Lipids of Marine Organisms: Molecular Biodiversity, Roles as Biomarkers, Biologically Active Compounds, and Economical Aspects

Cited by 252 publications

References 380 publications

The inhibition of TNF-α-induced NF-κB activation by marine natural products

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Lipids in Marine Ecosystems

Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA

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